Seroatlas · Human Serome Atlas

SLC41A2

Solute carrier family 41 member 2

Also known as: DKFZP434K0427, S41A2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96JW4
Gene: SLC41A2
Ensembl: ENSG00000136052
Chromosome: 12
Canonical length: 573 aa
Protein class: Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to enable magnesium ion transmembrane transporter activity. Involved in magnesium ion transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

573 residues, UniProt reviewed canonical sequence.

>Q96JW4|SLC41A2
     1  MTNSKGRSIT DKTSGGPSSG GGFVDWTLRL NTIQSDKFLN LLLSMVPVIY QKNQEDRHKK
    61  ANGIWQDGLS TAVQTFSNRS EQHMEYHSFS EQSFHANNGH ASSSCSQKYD DYANYNYCDG
   121  RETSETTAML QDEDISSDGD EDAIVEVTPK LPKESSGIMA LQILVPFLLA GFGTVSAGMV
   181  LDIVQHWEVF RKVTEVFILV PALLGLKGNL EMTLASRLST AVNIGKMDSP IEKWNLIIGN
   241  LALKQVQATV VGFLAAVAAI ILGWIPEGKY YLDHSILLCS SSVATAFIAS LLQGIIMVGV
   301  IVGSKKTGIN PDNVATPIAA SFGDLITLAI LAWISQGLYS CLETYYYISP LVGVFFLALT
   361  PIWIIIAAKH PATRTVLHSG WEPVITAMVI SSIGGLILDT TVSDPNLVGI VVYTPVINGI
   421  GGNLVAIQAS RISTYLHLHS IPGELPDEPK GCYYPFRTFF GPGVNNKSAQ VLLLLVIPGH
   481  LIFLYTIHLM KSGHTSLTII FIVVYLFGAV LQVFTLLWIA DWMVHHFWRK GKDPDSFSIP
   541  YLTALGDLLG TALLALSFHF LWLIGDRDGD VGD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC41A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 11
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 86 nTPM

Expression across tissuesHPA

Tissue

liver: 86 nTPM
stomach: 27 nTPM
duodenum: 20 nTPM
small intestine: 18 nTPM
colon: 15 nTPM
epididymis: 13 nTPM

Single-cell type

mucous neck cells: 285 nCPM
foveolar cells: 253 nCPM
sertoli cells: 251 nCPM
gastric chief cells: 210 nCPM
pdcs: 203 nCPM
enterocytes: 201 nCPM

Immune cell

plasmacytoid DC: 9.1 nTPM
myeloid DC: 3.1 nTPM
MAIT T-cell: 0.7 nTPM
memory B-cell: 0.4 nTPM
naive CD4 T-cell: 0.3 nTPM
classical monocyte: 0.2 nTPM

Brain region

hypothalamus: 47 nTPM
choroid plexus: 45 nTPM
cerebellum: 42 nTPM
cerebral cortex: 41 nTPM
pons: 38 nTPM
basal ganglia: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.33
gnomAD pLI: 0.97
gnomAD missense Z: 1.78
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

magnesium ion transmembrane transporter activity

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC41A2 as an antibody target. Whether an autoantibody or antibody against SLC41A2 could matter depends on whether native SLC41A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC41A2 is annotated at the cell surface, where native SLC41A2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC41A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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