Seroatlas · Human Serome Atlas

SLC41A1

Solute carrier family 41 member 1

Also known as: MgtE, S41A1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IVJ1
Gene
SLC41A1
Ensembl
ENSG00000133065
Chromosome
1
Canonical length
513 aa
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location
Mitochondria

OverviewNCBI Gene

Enables magnesium:sodium antiporter activity. Involved in cellular response to magnesium ion; intracellular magnesium ion homeostasis; and magnesium ion transmembrane transport. Located in basolateral plasma membrane. Part of protein-containing complex. Implicated in nephronophthisis. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

513 residues, UniProt reviewed canonical sequence.

>Q8IVJ1|SLC41A1
     1  MSSKPEPKDV HQLNGTGPSA SPCSSDGPGR EPLAGTSEFL GPDGAGVEVV IESRANAKGV
    61  REEDALLENG SQSNESDDVS TDRGPAPPSP LKETSFSIGL QVLFPFLLAG FGTVAAGMVL
   121  DIVQHWEVFQ KVTEVFILVP ALLGLKGNLE MTLASRLSTA ANIGHMDTPK ELWRMITGNM
   181  ALIQVQATVV GFLASIAAVV FGWIPDGHFS IPHAFLLCAS SVATAFIASL VLGMIMIGVI
   241  IGSRKIGINP DNVATPIAAS LGDLITLALL SGISWGLYLE LNHWRYIYPL VCAFFVALLP
   301  VWVVLARRSP ATREVLYSGW EPVIIAMAIS SVGGLILDKT VSDPNFAGMA VFTPVINGVG
   361  GNLVAVQASR ISTFLHMNGM PGENSEQAPR RCPSPCTTFF SPDVNSRSAR VLFLLVVPGH
   421  LVFLYTISCM QGGHTTLTLI FIIFYMTAAL LQVLILLYIA DWMVHWMWGR GLDPDNFSIP
   481  YLTALGDLLG TGLLALSFHV LWLIGDRDTD VGD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC41A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
10
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
93 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 93 nTPM
  • tongue: 71 nTPM
  • pancreas: 58 nTPM
  • skeletal muscle: 46 nTPM
  • testis: 17 nTPM
  • thyroid gland: 17 nTPM

Single-cell type

  • cardiomyocytes: 351 nCPM
  • choroid plexus epithelial cells: 114 nCPM
  • breast lactating cells: 91 nCPM
  • innate lymphoid cells: 77 nCPM
  • salivary myoepithelial cells: 72 nCPM
  • sertoli cells: 71 nCPM

Immune cell

  • MAIT T-cell: 2 nTPM
  • gdT-cell: 1.6 nTPM
  • memory CD4 T-cell: 1.5 nTPM
  • memory CD8 T-cell: 1.5 nTPM
  • naive CD8 T-cell: 1.5 nTPM
  • T-reg: 1.5 nTPM

Brain region

  • choroid plexus: 91 nTPM
  • thalamus: 43 nTPM
  • medulla oblongata: 37 nTPM
  • cerebellum: 36 nTPM
  • basal ganglia: 35 nTPM
  • amygdala: 35 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC41A1.

Disease | AllUniProt

Conditions SLC41A1 is implicated in, by any mechanism.

  • Nephronophthisis-like nephropathy 2 (NPHPL2) MIM:619468

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 159 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Nephronophthisis-like nephropathy 2

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.44
gnomAD pLI
0.65
gnomAD missense Z
1.48
DepMap mean gene effect
-0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC41A1 as an antibody target. Whether an autoantibody or antibody against SLC41A1 could matter depends on whether native SLC41A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC41A1 is annotated at the cell surface, where native SLC41A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC41A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC41A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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