Seroatlas · Human Serome Atlas

SLC38A6

Solute carrier family 38 member 6

Also known as: NAT-1, S38A6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IZM9
Gene: SLC38A6
Ensembl: ENSG00000139974
Chromosome: 14
Canonical length: 456 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Plasma membrane,Cell Junctions,Microtubules

OverviewNCBI Gene

Predicted to enable L-glutamate transmembrane transporter activity and L-glutamine transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport and glutamine transport. Predicted to be located in membrane and synapse. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

456 residues, UniProt reviewed canonical sequence.

>Q8IZM9|SLC38A6
     1  MEASWGSFNA ERGWYVSVQQ PEEAEAEELS PLLSNELHRQ RSPGVSFGLS VFNLMNAIMG
    61  SGILGLAYVL ANTGVFGFSF LLLTVALLAS YSVHLLLSMC IQTAVTSYED LGLFAFGLPG
   121  KLVVAGTIII QNIGAMSSYL LIIKTELPAA IAEFLTGDYS RYWYLDGQTL LIIICVGIVF
   181  PLALLPKIGF LGYTSSLSFF FMMFFALVVI IKKWSIPCPL TLNYVEKGFQ ISNVTDDCKP
   241  KLFHFSKESA YALPTMAFSF LCHTSILPIY CELQSPSKKR MQNVTNTAIA LSFLIYFISA
   301  LFGYLTFYDK VESELLKGYS KYLSHDVVVM TVKLCILFAV LLTVPLIHFP ARKAVTMMFF
   361  SNFPFSWIRH FLITLALNII IVLLAIYVPD IRNVFGVVGA STSTCLIFIF PGLFYLKLSR
   421  EDFLSWKKLG AFVLLIFGIL VGNFSLALII FDWINK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC38A6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 10
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 20 nTPM
epididymis: 13 nTPM
kidney: 11 nTPM
gallbladder: 9.3 nTPM
placenta: 9 nTPM
adrenal gland: 8.7 nTPM

Single-cell type

late spermatids: 221 nCPM
early spermatids: 200 nCPM
hofbauer cells: 186 nCPM
late primary spermatocytes: 159 nCPM
ependymal cells: 144 nCPM
myonuclei: 138 nCPM

Immune cell

intermediate monocyte: 7.1 nTPM
classical monocyte: 6.5 nTPM
non-classical monocyte: 4.5 nTPM
T-reg: 4.5 nTPM
plasmacytoid DC: 4.3 nTPM
myeloid DC: 3.6 nTPM

Brain region

cerebral cortex: 23 nTPM
choroid plexus: 22 nTPM
hypothalamus: 19 nTPM
thalamus: 18 nTPM
basal ganglia: 18 nTPM
white matter: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.46
gnomAD pLI: 0
gnomAD missense Z: -0.47
DepMap mean gene effect: 0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC38A6 as an antibody target. Whether an autoantibody or antibody against SLC38A6 could matter depends on whether native SLC38A6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC38A6 is annotated at the cell surface, where native SLC38A6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC38A6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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