Seroatlas · Human Serome Atlas

SLC38A5

Sodium-coupled neutral amino acid transporter 5

Also known as: JM24, S38A5_HUMAN, SN2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WUX1
Gene
SLC38A5
Ensembl
ENSG00000017483
Chromosome
X
Canonical length
472 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location
Vesicles,Plasma membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a system N sodium-coupled amino acid transporter. The encoded protein transports glutamine, asparagine, histidine, serine, alanine, and glycine across the cell membrane, but does not transport charged amino acids, imino acids, or N-alkylated amino acids. Alternative splicing results in multiple transcript variants, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

472 residues, UniProt reviewed canonical sequence.

>Q8WUX1|SLC38A5
     1  MELQDPKMNG ALPSDAVGYR QEREGFLPSR GPAPGSKPVQ FMDFEGKTSF GMSVFNLSNA
    61  IMGSGILGLA YAMAHTGVIF FLALLLCIAL LSSYSIHLLL TCAGIAGIRA YEQLGQRAFG
   121  PAGKVVVATV ICLHNVGAMS SYLFIIKSEL PLVIGTFLYM DPEGDWFLKG NLLIIIVSVL
   181  IILPLALMKH LGYLGYTSGL SLTCMLFFLV SVIYKKFQLG CAIGHNETAM ESEALVGLPS
   241  QGLNSSCEAQ MFTVDSQMSY TVPIMAFAFV CHPEVLPIYT ELCRPSKRRM QAVANVSIGA
   301  MFCMYGLTAT FGYLTFYSSV KAEMLHMYSQ KDPLILCVRL AVLLAVTLTV PVVLFPIRRA
   361  LQQLLFPGKA FSWPRHVAIA LILLVLVNVL VICVPTIRDI FGVIGSTSAP SLIFILPSIF
   421  YLRIVPSEVE PFLSWPKIQA LCFGVLGVLF MAVSLGFMFA NWATGQSRMS GH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC38A5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
11
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
224 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 224 nTPM
  • bone marrow: 53 nTPM
  • lung: 24 nTPM
  • hippocampal formation: 21 nTPM
  • skin: 20 nTPM
  • spinal cord: 20 nTPM

Single-cell type

  • pancreatic acinar cells: 121 nCPM
  • erythrocyte progenitors: 96 nCPM
  • plasma cells: 71 nCPM
  • gastric chief cells: 45 nCPM
  • erythrocytes: 39 nCPM
  • basal keratinocytes: 34 nCPM

Immune cell

  • MAIT T-cell: 24 nTPM
  • T-reg: 22 nTPM
  • memory CD4 T-cell: 19 nTPM
  • gdT-cell: 17 nTPM
  • memory CD8 T-cell: 16 nTPM
  • plasmacytoid DC: 13 nTPM

Brain region

  • thalamus: 47 nTPM
  • medulla oblongata: 46 nTPM
  • amygdala: 45 nTPM
  • pons: 41 nTPM
  • midbrain: 31 nTPM
  • cerebellum: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.3
gnomAD pLI
0.98
gnomAD missense Z
2.44
DepMap mean gene effect
0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC38A5 as an antibody target. Whether an autoantibody or antibody against SLC38A5 could matter depends on whether native SLC38A5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC38A5 is annotated at the cell surface, where native SLC38A5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC38A5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC38A5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...