Seroatlas · Human Serome Atlas

SLC38A4

Sodium-coupled neutral amino acid transporter 4

Also known as: ATA3, NAT3, PAAT, S38A4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q969I6
Gene: SLC38A4
Ensembl: ENSG00000139209
Chromosome: 12
Canonical length: 547 aa
Protein class: FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

SLC38A4 is found predominantly in liver and transports both cationic and neutral amino acids. The transport of cationic amino acids by SLC38A4 is Na(+) and pH independent, while the transport of neutral amino acids is Na(+) and pH dependent (Hatanaka et al., 2001 [PubMed 11342143]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

547 residues, UniProt reviewed canonical sequence.

>Q969I6|SLC38A4
     1  MDPMELRNVN IEPDDESSSG ESAPDSYIGI GNSEKAAMSS QFANEDTESQ KFLTNGFLGK
    61  KKLADYADEH HPGTTSFGMS SFNLSNAIMG SGILGLSYAM ANTGIILFII MLLAVAILSL
   121  YSVHLLLKTA KEGGSLIYEK LGEKAFGWPG KIGAFVSITM QNIGAMSSYL FIIKYELPEV
   181  IRAFMGLEEN TGEWYLNGNY LIIFVSVGII LPLSLLKNLG YLGYTSGFSL TCMVFFVSVV
   241  IYKKFQIPCP LPVLDHSVGN LSFNNTLPMH VVMLPNNSES SDVNFMMDYT HRNPAGLDEN
   301  QAKGSLHDSG VEYEAHSDDK CEPKYFVFNS RTAYAIPILV FAFVCHPEVL PIYSELKDRS
   361  RRKMQTVSNI SITGMLVMYL LAALFGYLTF YGEVEDELLH AYSKVYTLDI PLLMVRLAVL
   421  VAVTLTVPIV LFPIRTSVIT LLFPKRPFSW IRHFLIAAVL IALNNVLVIL VPTIKYIFGF
   481  IGASSATMLI FILPAVFYLK LVKKETFRSP QKVGALIFLV VGIFFMIGSM ALIIIDWIYD
   541  PPNSKHH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC38A4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 10
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 570 nTPM

Expression across tissuesHPA

Tissue

liver: 570 nTPM
skeletal muscle: 9.3 nTPM
pancreas: 6.1 nTPM
smooth muscle: 5 nTPM
colon: 4.8 nTPM
kidney: 4.1 nTPM

Single-cell type

hepatocytes: 536 nCPM
myonuclei: 124 nCPM
cardiomyocytes: 95 nCPM
pancreatic islet cells: 94 nCPM
thymic myoid cells: 93 nCPM
epicardial cells: 71 nCPM

Immune cell

basophil: 0.7 nTPM
NK-cell: 0.3 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

hypothalamus: 2.3 nTPM
choroid plexus: 1.8 nTPM
midbrain: 1.6 nTPM
white matter: 1.6 nTPM
amygdala: 1.4 nTPM
cerebral cortex: 1.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.41
gnomAD pLI: 0.56
gnomAD missense Z: 1.5
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC38A4 as an antibody target. Whether an autoantibody or antibody against SLC38A4 could matter depends on whether native SLC38A4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC38A4 is annotated at the cell surface, where native SLC38A4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC38A4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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