Seroatlas · Human Serome Atlas

SLC38A3

Sodium-coupled neutral amino acid transporter 3

Also known as: G17, S38A3_HUMAN, SN1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q99624
Gene
SLC38A3
Ensembl
ENSG00000188338
Chromosome
3
Canonical length
504 aa
Protein class
Disease related genes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Microtubules,Cytosol

OverviewNCBI Gene

Enables L-amino acid transmembrane transporter activity. Involved in carboxylic acid transport. Located in plasma membrane. Implicated in developmental and epileptic encephalopathy 102. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

504 residues, UniProt reviewed canonical sequence.

>Q99624|SLC38A3
     1  MEAPLQTEMV ELVPNGKHSE GLLPVITPMA GNQRVEDPAR SCMEGKSFLQ KSPSKEPHFT
    61  DFEGKTSFGM SVFNLSNAIM GSGILGLAYA MANTGIILFL FLLTAVALLS SYSIHLLLKS
   121  SGVVGIRAYE QLGYRAFGTP GKLAAALAIT LQNIGAMSSY LYIIKSELPL VIQTFLNLEE
   181  KTSDWYMNGN YLVILVSVTI ILPLALMRQL GYLGYSSGFS LSCMVFFLIA VIYKKFHVPC
   241  PLPPNFNNTT GNFSHVEIVK EKVQLQVEPE ASAFCTPSYF TLNSQTAYTI PIMAFAFVCH
   301  PEVLPIYTEL KDPSKKKMQH ISNLSIAVMY IMYFLAALFG YLTFYNGVES ELLHTYSKVD
   361  PFDVLILCVR VAVLTAVTLT VPIVLFPVRR AIQQMLFPNQ EFSWLRHVLI AVGLLTCINL
   421  LVIFAPNILG IFGVIGATSA PFLIFIFPAI FYFRIMPTEK EPARSTPKIL ALCFAMLGFL
   481  LMTMSLSFII IDWASGTSRH GGNH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC38A3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
10
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
310 nTPM

Expression across tissuesHPA

Tissue

  • liver: 310 nTPM
  • retina: 161 nTPM
  • pancreas: 36 nTPM
  • skeletal muscle: 34 nTPM
  • tongue: 33 nTPM
  • spinal cord: 23 nTPM

Single-cell type

  • hepatocytes: 135 nCPM
  • cone photoreceptor cells: 120 nCPM
  • müller glia: 79 nCPM
  • rod photoreceptor cells: 77 nCPM
  • retinal bipolar cells: 68 nCPM
  • retinal pigment epithelial cells: 43 nCPM

Immune cell

  • basophil: 2.8 nTPM
  • neutrophil: 0.8 nTPM
  • eosinophil: 0.3 nTPM
  • NK-cell: 0.3 nTPM
  • memory B-cell: 0.2 nTPM
  • naive B-cell: 0.2 nTPM

Brain region

  • midbrain: 53 nTPM
  • cerebellum: 48 nTPM
  • thalamus: 44 nTPM
  • medulla oblongata: 43 nTPM
  • pons: 41 nTPM
  • white matter: 39 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC38A3.

Disease | AllUniProt

Conditions SLC38A3 is implicated in, by any mechanism.

  • Developmental and epileptic encephalopathy 102 (DEE102) MIM:619881

Disease | GeneticClinVar

7 pathogenic / likely-pathogenic of 72 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Developmental and epileptic encephalopathy 102

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC38A3 as an antibody target. Whether an autoantibody or antibody against SLC38A3 could matter depends on whether native SLC38A3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC38A3 is annotated at the cell surface, where native SLC38A3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC38A3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC38A3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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