Seroatlas · Human Serome Atlas

SLC38A2

Sodium-coupled neutral amino acid symporter 2

Also known as: ATA2, KIAA1382, S38A2_HUMAN, SAT2, SNAT2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96QD8
Gene
SLC38A2
Ensembl
ENSG00000134294
Chromosome
12
Canonical length
506 aa
Protein class
FDA approved drug targets, Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane

OverviewNCBI Gene

Enables neutral L-amino acid:sodium symporter activity. Involved in several processes, including cellular response to arsenite(3-); neutral amino acid transport; and positive regulation of RNA splicing. Located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

506 residues, UniProt reviewed canonical sequence.

>Q96QD8|SLC38A2
     1  MKKAEMGRFS ISPDEDSSSY SSNSDFNYSY PTKQAALKSH YADVDPENQN FLLESNLGKK
    61  KYETEFHPGT TSFGMSVFNL SNAIVGSGIL GLSYAMANTG IALFIILLTF VSIFSLYSVH
   121  LLLKTANEGG SLLYEQLGYK AFGLVGKLAA SGSITMQNIG AMSSYLFIVK YELPLVIQAL
   181  TNIEDKTGLW YLNGNYLVLL VSLVVILPLS LFRNLGYLGY TSGLSLLCMV FFLIVVICKK
   241  FQVPCPVEAA LIINETINTT LTQPTALVPA LSHNVTENDS CRPHYFIFNS QTVYAVPILI
   301  FSFVCHPAVL PIYEELKDRS RRRMMNVSKI SFFAMFLMYL LAALFGYLTF YEHVESELLH
   361  TYSSILGTDI LLLIVRLAVL MAVTLTVPVV IFPIRSSVTH LLCASKDFSW WRHSLITVSI
   421  LAFTNLLVIF VPTIRDIFGF IGASAASMLI FILPSAFYIK LVKKEPMKSV QKIGALFFLL
   481  SGVLVMTGSM ALIVLDWVHN APGGGH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC38A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
11
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
287 nTPM

Expression across tissuesHPA

Tissue

  • liver: 287 nTPM
  • skin: 193 nTPM
  • tongue: 163 nTPM
  • placenta: 152 nTPM
  • gallbladder: 123 nTPM
  • lung: 113 nTPM

Single-cell type

  • basal keratinocytes: 1,107 nCPM
  • suprabasal keratinocytes: 912 nCPM
  • endometrial glandular cells: 608 nCPM
  • lymphatic endothelial cells: 557 nCPM
  • neutrophils: 509 nCPM
  • breast hormone-responsive cells: 469 nCPM

Immune cell

  • NK-cell: 52 nTPM
  • basophil: 41 nTPM
  • plasmacytoid DC: 41 nTPM
  • myeloid DC: 35 nTPM
  • total PBMC: 27 nTPM
  • classical monocyte: 25 nTPM

Brain region

  • white matter: 132 nTPM
  • cerebellum: 96 nTPM
  • pons: 94 nTPM
  • medulla oblongata: 91 nTPM
  • basal ganglia: 82 nTPM
  • hypothalamus: 79 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.24
gnomAD pLI
1
gnomAD missense Z
0.8
DepMap mean gene effect
-0.46
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC38A2 as an antibody target. Whether an autoantibody or antibody against SLC38A2 could matter depends on whether native SLC38A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC38A2 is annotated at the cell surface, where native SLC38A2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC38A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC38A2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...