SLC38A11
Putative sodium-coupled neutral amino acid transporter 11
Also known as: AVT2, FLJ39822, S38AB_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q08AI6
- Gene
- SLC38A11
- Ensembl
- ENSG00000169507
- Chromosome
- 2
- Canonical length
- 406 aa
- Protein class
- Predicted membrane proteins, Transporters
OverviewNCBI Gene
Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
406 residues, UniProt reviewed canonical sequence.
>Q08AI6|SLC38A11
1 MKQAGFPLGI LLLFWVSYVT DFSLVLLIKG GALSGTDTYQ SLVNKTFGFP GYLLLSVLQF
61 LYPFIAMISY NIIAGDTLSK VFQRIPGVDP ENVFIGRHFI IGLSTVTFTL PLSLYRNIAK
121 LGKVSLISTG LTTLILGIVM ARAISLGPHI PKTEDAWVFA KPNAIQAVGV MSFAFICHHN
181 SFLVYSSLEE PTVAKWSRLI HMSIVISVFI CIFFATCGYL TFTGFTQGDL FENYCRNDDL
241 VTFGRFCYGV TVILTYPMEC FVTREVIANV FFGGNLSSVF HIVVTVMVIT VATLVSLLID
301 CLGIVLELNG VLCATPLIFI IPSACYLKLS EEPRTHSDKI MSCVMLPIGA VVMVFGFVMA
361 ITNTQDCTHG QEMFYCFPDN FSLTNTSESH VQQTTQLSTL NISIFQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SLC38A11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 10
- Mean surface accessibility (rSASA)
- 0.27
- Highest tissue expression
- 30 nTPM
Expression across tissuesHPA
Tissue
- epididymis: 30 nTPM
- choroid plexus: 24 nTPM
- seminal vesicle: 13 nTPM
- gallbladder: 13 nTPM
- prostate: 8.3 nTPM
- stomach: 7.9 nTPM
Single-cell type
- neuroendocrine cells: 657 nCPM
- choroid plexus epithelial cells: 302 nCPM
- vascular smooth muscle cells: 261 nCPM
- adrenal medulla cells: 245 nCPM
- mast cells: 224 nCPM
- renal connecting tubule cells: 202 nCPM
Immune cell
- naive B-cell: 3.8 nTPM
- memory B-cell: 1.6 nTPM
- total PBMC: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
Brain region
- choroid plexus: 51 nTPM
- cerebral cortex: 17 nTPM
- basal ganglia: 7.3 nTPM
- white matter: 7.1 nTPM
- amygdala: 6.9 nTPM
- hippocampal formation: 6.9 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.7
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.08
- DepMap mean gene effect
- -0.05
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SLC38A11 as an antibody target. Whether an autoantibody or antibody against SLC38A11 could matter depends on whether native SLC38A11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SLC38A11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SLC38A11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...