Seroatlas · Human Serome Atlas

SLC38A10

Solute carrier family 38 member 10

Also known as: MGC15523, PP1744, S38AA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HBR0
Gene: SLC38A10
Ensembl: ENSG00000157637
Chromosome: 17
Canonical length: 1119 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Golgi apparatus

OverviewNCBI Gene

Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Predicted to act upstream of or within bone development. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1119 residues, UniProt reviewed canonical sequence.

>Q9HBR0|SLC38A10
     1  MTAAAASNWG LITNIVNSIV GVSVLTMPFC FKQCGIVLGA LLLVFCSWMT HQSCMFLVKS
    61  ASLSKRRTYA GLAFHAYGKA GKMLVETSMI GLMLGTCIAF YVVIGDLGSN FFARLFGFQV
   121  GGTFRMFLLF AVSLCIVLPL SLQRNMMASI QSFSAMALLF YTVFMFVIVL SSLKHGLFSG
   181  QWLRRVSYVR WEGVFRCIPI FGMSFACQSQ VLPTYDSLDE PSVKTMSSIF ASSLNVVTTF
   241  YVMVGFFGYV SFTEATAGNV LMHFPSNLVT EMLRVGFMMS VAVGFPMMIL PCRQALSTLL
   301  CEQQQKDGTF AAGGYMPPLR FKALTLSVVF GTMVGGILIP NVETILGLTG ATMGSLICFI
   361  CPALIYKKIH KNALSSQVVL WVGLGVLVVS TVTTLSVSEE VPEDLAEEAP GGRLGEAEGL
   421  MKVEAARLSA QDPVVAVAED GREKPKLPKE REELEQAQIK GPVDVPGRED GKEAPEEAQL
   481  DRPGQGIAVP VGEAHRHEPP VPHDKVVVDE GQDREVPEEN KPPSRHAGGK APGVQGQMAP
   541  PLPDSEREKQ EPEQGEVGKR PGQAQALEEA GDLPEDPQKV PEADGQPAVQ PAKEDLGPGD
   601  RGLHPRPQAV LSEQQNGLAV GGGEKAKGGP PPGNAAGDTG QPAEDSDHGG KPPLPAEKPA
   661  PGPGLPPEPR EQRDVERAGG NQAASQLEEA GRAEMLDHAV LLQVIKEQQV QQKRLLDQQE
   721  KLLAVIEEQH KEIHQQRQED EEDKPRQVEV HQEPGAAVPR GQEAPEGKAR ETVENLPPLP
   781  LDPVLRAPGG RPAPSQDLNQ RSLEHSEGPV GRDPAGPPDG GPDTEPRAAQ AKLRDGQKDA
   841  APRAAGTVKE LPKGPEQVPV PDPAREAGGP EERLAEEFPG QSQDVTGGSQ DRKKPGKEVA
   901  ATGTSILKEA NWLVAGPGAE TGDPRMKPKQ VSRDLGLAAD LPGGAEGAAA QPQAVLRQPE
   961  LRVISDGEQG GQQGHRLDHG GHLEMRKARG GDHVPVSHEQ PRGGEDAAVQ EPRQRPEPEL
  1021  GLKRAVPGGQ RPDNAKPNRD LKLQAGSDLR RRRRDLGPHA EGQLAPRDGV IIGLNPLPDV
  1081  QVNDLRGALD AQLRQAAGGA LQVVHSRQLR QAPGPPEES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC38A10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 10
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 88 nTPM

Expression across tissuesHPA

Tissue

pancreas: 88 nTPM
liver: 73 nTPM
pituitary gland: 60 nTPM
salivary gland: 48 nTPM
blood vessel: 47 nTPM
spleen: 43 nTPM

Single-cell type

late spermatids: 126 nCPM
plasma cells: 122 nCPM
neutrophil progenitors: 121 nCPM
monocyte progenitors: 111 nCPM
neutrophils: 106 nCPM
gonadotrophs: 100 nCPM

Immune cell

eosinophil: 19 nTPM
non-classical monocyte: 16 nTPM
basophil: 13 nTPM
intermediate monocyte: 12 nTPM
classical monocyte: 11 nTPM
plasmacytoid DC: 9.8 nTPM

Brain region

medulla oblongata: 56 nTPM
white matter: 50 nTPM
cerebral cortex: 48 nTPM
thalamus: 46 nTPM
pons: 44 nTPM
midbrain: 43 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.86
gnomAD pLI: 0
gnomAD missense Z: 0.57
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

L-amino acid transmembrane transporter activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC38A10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

HLA-DPA1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC38A10 as an antibody target. Whether an autoantibody or antibody against SLC38A10 could matter depends on whether native SLC38A10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC38A10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC38A10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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