Seroatlas · Human Serome Atlas

SLC36A4

Neutral amino acid uniporter 4

Also known as: FLJ38932, PAT4, S36A4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6YBV0
Gene
SLC36A4
Ensembl
ENSG00000180773
Chromosome
11
Canonical length
504 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location
Golgi apparatus,Plasma membrane,Cytosol

OverviewNCBI Gene

SLC36A4 belongs to the SLC36 family of amino acid transporters based on sequence similarity with other family members (e.g., SLC36A1; MIM 606561). SLC36 proteins contain about 500 amino acids and have 9 to 11 transmembrane domains. Unlike other SLC36 family members, which are proton-coupled amino acid transporters, SLC36A4 is a high-affinity/low-capacity non-proton-coupled amino acid transporter (Pillai and Meredith, 2011 [PubMed 21097500]).[supplied by OMIM, Feb 2011]

Canonical amino-acid sequenceUniProt

504 residues, UniProt reviewed canonical sequence.

>Q6YBV0|SLC36A4
     1  MEAAATPAAA GAARREELDM DVMRPLINEQ NFDGTSDEEH EQELLPVQKH YQLDDQEGIS
    61  FVQTLMHLLK GNIGTGLLGL PLAIKNAGIV LGPISLVFIG IISVHCMHIL VRCSHFLCLR
   121  FKKSTLGYSD TVSFAMEVSP WSCLQKQAAW GRSVVDFFLV ITQLGFCSVY IVFLAENVKQ
   181  VHEGFLESKV FISNSTNSSN PCERRSVDLR IYMLCFLPFI ILLVFIRELK NLFVLSFLAN
   241  VSMAVSLVII YQYVVRNMPD PHNLPIVAGW KKYPLFFGTA VFAFEGIGVV LPLENQMKES
   301  KRFPQALNIG MGIVTTLYVT LATLGYMCFH DEIKGSITLN LPQDVWLYQS VKILYSFGIF
   361  VTYSIQFYVP AEIIIPGITS KFHTKWKQIC EFGIRSFLVS ITCAGAILIP RLDIVISFVG
   421  AVSSSTLALI LPPLVEILTF SKEHYNIWMV LKNISIAFTG VVGFLLGTYI TVEEIIYPTP
   481  KVVAGTPQSP FLNLNSTCLT SGLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC36A4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
10
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 18 nTPM
  • retina: 14 nTPM
  • cerebellum: 9.1 nTPM
  • kidney: 8.8 nTPM
  • appendix: 8.7 nTPM
  • thyroid gland: 8.3 nTPM

Single-cell type

  • neutrophils: 537 nCPM
  • neutrophil progenitors: 491 nCPM
  • monocyte progenitors: 256 nCPM
  • monocytes: 215 nCPM
  • somatotrophs: 208 nCPM
  • lactotrophs: 193 nCPM

Immune cell

  • eosinophil: 5.3 nTPM
  • classical monocyte: 4.9 nTPM
  • intermediate monocyte: 2.6 nTPM
  • myeloid DC: 1.9 nTPM
  • non-classical monocyte: 1.7 nTPM
  • naive CD4 T-cell: 1.5 nTPM

Brain region

  • hypothalamus: 25 nTPM
  • cerebellum: 24 nTPM
  • pons: 23 nTPM
  • midbrain: 21 nTPM
  • white matter: 21 nTPM
  • choroid plexus: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.59
gnomAD pLI
0
gnomAD missense Z
-0.04
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC36A4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC36A4 as an antibody target. Whether an autoantibody or antibody against SLC36A4 could matter depends on whether native SLC36A4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC36A4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC36A4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC36A4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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