Seroatlas · Human Serome Atlas

SLC36A3

Proton-coupled amino acid transporter 3

Also known as: PAT3, S36A3_HUMAN, TRAMD2, tramdorin2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q495N2
Gene: SLC36A3
Ensembl: ENSG00000186334
Chromosome: 5
Canonical length: 470 aa
Protein class: Metabolic proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to enable amino acid transmembrane transporter activity. Predicted to be involved in carboxylic acid transport and proton transmembrane transport. Predicted to be located in membrane. Predicted to be active in vacuolar membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

470 residues, UniProt reviewed canonical sequence.

>Q495N2|SLC36A3
     1  MSLLGRDYNS ELNSLDNGPQ SPSESSSSIT SENVHPAGEA GLSMMQTLIH LLKCNIGTGL
    61  LGLPLAIKNA GLLVGPVSLL AIGVLTVHCM VILLNCAQHL SQRLQKTFVN YGEATMYGLE
   121  TCPNTWLRAH AVWGRYTVSF LLVITQLGFC SVYFMFMADN LQQMVEKAHV TSNICQPREI
   181  LTLTPILDIR FYMLIILPFL ILLVFIQNLK VLSVFSTLAN ITTLGSMALI FEYIMEGIPY
   241  PSNLPLMANW KTFLLFFGTA IFTFEGVGMV LPLKNQMKHP QQFSFVLYLG MSIVIILYIL
   301  LGTLGYMKFG SDTQASITLN LPNCWLYQSV KLMYSIGIFF TYALQFHVPA EIIIPFAISQ
   361  VSESWALFVD LSVRSALVCL TCVSAILIPR LDLVISLVGS VSSSALALII PALLEIVIFY
   421  SEDMSCVTIA KDIMISIVGL LGCIFGTYQA LYELPQPISH SMANSTGVHA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC36A3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 11
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 7 nTPM

Expression across tissuesHPA

Tissue

testis: 7 nTPM
pancreas: 0.2 nTPM
epididymis: 0.1 nTPM
skin: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

late spermatids: 226 nCPM
early spermatids: 88 nCPM
late primary spermatocytes: 13 nCPM
retinal ganglion cells: 3.9 nCPM
epididymal basal cells: 3.2 nCPM
cdc: 2.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.71
gnomAD pLI: 0
gnomAD missense Z: -0.09
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

vacuolar membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC36A3 as an antibody target. Whether an autoantibody or antibody against SLC36A3 could matter depends on whether native SLC36A3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC36A3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC36A3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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