Seroatlas · Human Serome Atlas

SLC36A2

Proton-coupled amino acid transporter 2

Also known as: PAT2, S36A2_HUMAN, TRAMD1, tramdorin

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q495M3
Gene
SLC36A2
Ensembl
ENSG00000186335
Chromosome
5
Canonical length
483 aa
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a pH-dependent proton-coupled amino acid transporter that belongs to the amino acid auxin permease 1 protein family. The encoded protein primarily transports small amino acids such as glycine, alanine and proline. Mutations in this gene are associated with iminoglycinuria and hyperglycinuria. [provided by RefSeq, Sep 2010]

Canonical amino-acid sequenceUniProt

483 residues, UniProt reviewed canonical sequence.

>Q495M3|SLC36A2
     1  MSVTKSTEGP QGAVAIKLDL MSPPESAKKL ENKDSTFLDE SPSESAGLKK TKGITVFQAL
    61  IHLVKGNMGT GILGLPLAVK NAGILMGPLS LLVMGFIACH CMHILVKCAQ RFCKRLNKPF
   121  MDYGDTVMHG LEANPNAWLQ NHAHWGRHIV SFFLIITQLG FCCVYIVFLA DNLKQVVEAV
   181  NSTTNNCYSN ETVILTPTMD SRLYMLSFLP FLVLLVLIRN LRILTIFSML ANISMLVSLV
   241  IIIQYITQEI PDPSRLPLVA SWKTYPLFFG TAIFSFESIG VVLPLENKMK NARHFPAILS
   301  LGMSIVTSLY IGMAALGYLR FGDDIKASIS LNLPNCWLYQ SVKLLYIAGI LCTYALQFYV
   361  PAEIIIPFAI SRVSTRWALP LDLSIRLVMV CLTCLLAILI PRLDLVISLV GSVSGTALAL
   421  IIPPLLEVTT FYSEGMSPLT IFKDALISIL GFVGFVVGTY QALDELLKSE DSHPFSNSTT
   481  FVR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC36A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
11
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
75 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 75 nTPM
  • kidney: 63 nTPM
  • tongue: 28 nTPM
  • testis: 0.9 nTPM
  • salivary gland: 0.8 nTPM
  • esophagus: 0.7 nTPM

Single-cell type

  • myonuclei: 738 nCPM
  • proximal tubule cells: 430 nCPM
  • early spermatids: 30 nCPM
  • late spermatids: 25 nCPM
  • distal convoluted tubule cells: 8.6 nCPM
  • late primary spermatocytes: 8.4 nCPM

Immune cell

  • neutrophil: 1.1 nTPM
  • basophil: 1 nTPM
  • naive B-cell: 0.4 nTPM
  • NK-cell: 0.4 nTPM
  • plasmacytoid DC: 0.4 nTPM
  • eosinophil: 0.3 nTPM

Brain region

  • cerebellum: 4 nTPM
  • cerebral cortex: 3.5 nTPM
  • pons: 2.9 nTPM
  • white matter: 2.8 nTPM
  • basal ganglia: 2.7 nTPM
  • amygdala: 2.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC36A2.

Disease | AllUniProt

Conditions SLC36A2 is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.26
gnomAD pLI
0
gnomAD missense Z
0.08
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC36A2 as an antibody target. Whether an autoantibody or antibody against SLC36A2 could matter depends on whether native SLC36A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC36A2 is annotated at the cell surface, where native SLC36A2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC36A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC36A2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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