Seroatlas · Human Serome Atlas

SLC36A1

Proton-coupled amino acid transporter 1

Also known as: LYAAT-1, PAT1, S36A1_HUMAN, TRAMD3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z2H8
Gene
SLC36A1
Ensembl
ENSG00000123643
Chromosome
5
Canonical length
476 aa
Protein class
Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a member of the eukaryote-specific amino acid/auxin permease (AAAP) 1 transporter family. The encoded protein functions as a proton-dependent, small amino acid transporter. This gene is clustered with related family members on chromosome 5q33.1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Canonical amino-acid sequenceUniProt

476 residues, UniProt reviewed canonical sequence.

>Q7Z2H8|SLC36A1
     1  MSTQRLRNED YHDYSSTDVS PEESPSEGLN NLSSPGSYQR FGQSNSTTWF QTLIHLLKGN
    61  IGTGLLGLPL AVKNAGIVMG PISLLIIGIV AVHCMGILVK CAHHFCRRLN KSFVDYGDTV
   121  MYGLESSPCS WLRNHAHWGR RVVDFFLIVT QLGFCCVYFV FLADNFKQVI EAANGTTNNC
   181  HNNETVILTP TMDSRLYMLS FLPFLVLLVF IRNLRALSIF SLLANITMLV SLVMIYQFIV
   241  QRIPDPSHLP LVAPWKTYPL FFGTAIFSFE GIGMVLPLEN KMKDPRKFPL ILYLGMVIVT
   301  ILYISLGCLG YLQFGANIQG SITLNLPNCW LYQSVKLLYS IGIFFTYALQ FYVPAEIIIP
   361  FFVSRAPEHC ELVVDLFVRT VLVCLTCILA ILIPRLDLVI SLVGSVSSSA LALIIPPLLE
   421  VTTFYSEGMS PLTIFKDALI SILGFVGFVV GTYEALYELI QPSNAPIFIN STCAFI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC36A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
11
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
97 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 97 nTPM
  • duodenum: 42 nTPM
  • cerebellum: 40 nTPM
  • small intestine: 37 nTPM
  • bone marrow: 28 nTPM
  • rectum: 21 nTPM

Single-cell type

  • early spermatids: 167 nCPM
  • breast lactating cells: 113 nCPM
  • neutrophils: 109 nCPM
  • enterocytes: 90 nCPM
  • adrenal medulla cells: 75 nCPM
  • neutrophil progenitors: 71 nCPM

Immune cell

  • basophil: 22 nTPM
  • neutrophil: 20 nTPM
  • classical monocyte: 8.7 nTPM
  • non-classical monocyte: 4.1 nTPM
  • intermediate monocyte: 3.8 nTPM
  • eosinophil: 3.6 nTPM

Brain region

  • cerebellum: 200 nTPM
  • cerebral cortex: 58 nTPM
  • pons: 51 nTPM
  • white matter: 48 nTPM
  • midbrain: 41 nTPM
  • basal ganglia: 41 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.9
gnomAD pLI
0
gnomAD missense Z
1.38
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC36A1 as an antibody target. Whether an autoantibody or antibody against SLC36A1 could matter depends on whether native SLC36A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC36A1 is annotated at the cell surface, where native SLC36A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC36A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC36A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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