Seroatlas · Human Serome Atlas

SLC35G6

Solute carrier family 35 member G6

Also known as: AMAC1L3, S35G6_HUMAN, TMEM21B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0C7Q6
Gene: SLC35G6
Ensembl: ENSG00000259224
Chromosome: 17
Canonical length: 338 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

338 residues, UniProt reviewed canonical sequence.

>P0C7Q6|SLC35G6
     1  MAGSHPYLNP PDSTHPSPPS APPSLRWHQC CQPSDATNGL LVALLGGGLP AGFVGPLSHM
    61  AYQASNLPSL ELLICRCLFH LPIALLLKLR GDPLLGPPDI RGRAYFYALL NVLSIGCAYS
   121  AVQVVPAGNA ATVRKGSSTV CSAVLTLCLE SQGLSGYDWC GLLGSILGLI IIVGPGLWTL
   181  QEGITGVYTA LGYGQAFVGG LALSLGLLVY RSLHFPSCLP TVAFLSGLVG LLGSVPGLFV
   241  LQPPVLPSDL PSWSCVGAVG ILALVSFTCV SYAVTKAHPA LVCAVLHSEV VVALILQYYM
   301  LHETVAPSDI VGAGVVLGSI AIITAWNLSC EREGKVEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC35G6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 9
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 5.3 nTPM

Expression across tissuesHPA

Tissue

testis: 5.3 nTPM
skeletal muscle: 0.4 nTPM
cerebellum: 0.2 nTPM
bone marrow: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

late primary spermatocytes: 1 nCPM
papillary tip epithelial cells: 0.4 nCPM
early spermatids: 0.3 nCPM
late spermatids: 0.2 nCPM
bergmann glia: 0.1 nCPM
brain excitatory neurons: 0.1 nCPM

Immune cell

neutrophil: 0.2 nTPM
naive B-cell: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

cerebral cortex: 1.2 nTPM
pons: 0.8 nTPM
white matter: 0.7 nTPM
cerebellum: 0.6 nTPM
hypothalamus: 0.6 nTPM
medulla oblongata: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.35
gnomAD pLI: 0
gnomAD missense Z: 0.04
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC35G6 as an antibody target. Whether an autoantibody or antibody against SLC35G6 could matter depends on whether native SLC35G6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC35G6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC35G6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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