Seroatlas · Human Serome Atlas

SLC35G5

Solute carrier family 35 member G5

Also known as: AMAC, AMAC1L2, S35G5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96KT7
Gene: SLC35G5
Ensembl: ENSG00000177710
Chromosome: 8
Canonical length: 338 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene is intronless and probably arose from retrotransposition of a similar gene. It has high sequence similarity to the gene encoding acyl-malonyl condensing enzyme on chromosome 17. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

338 residues, UniProt reviewed canonical sequence.

>Q96KT7|SLC35G5
     1  MAGSHPYFNL PDSTHPSPPS APPSLRWHQR CQPSGATNGL LVALLGGGLP AGFVGPLSRM
    61  AYQGSNLPSL ELLICRCLFH LPIALLLKLR GDPLLGPPDI RGWACFCALL NVLSIGCAYS
   121  AVQVVPAGNA ATVRKGSSTV CSAVLTLCLE SQGLGGYEWC GLLGSILGLI IILGPGLWTL
   181  QEGTTGVYTT LGYVQAFLGG LALSLGLLVY RSLHFPSCLP TVAFLSGLVG LLGCVPGLFV
   241  LQTPVLPSDL LSWSCVGAEG ILALVSFTCV GYAVTKAHPA LVCAVLHSEV VVALILQYYM
   301  LHETVALSDI MGAGVVLGSI AIITARNLSC ERTGKVEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC35G5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 9
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 2.2 nTPM

Expression across tissuesHPA

Tissue

testis: 2.2 nTPM
spleen: 0.5 nTPM
prostate: 0.4 nTPM
colon: 0.3 nTPM
heart muscle: 0.3 nTPM
pituitary gland: 0.3 nTPM

Single-cell type

astrocytes: 0.8 nCPM
distal convoluted tubule cells: 0.8 nCPM
oligodendrocyte progenitor cells: 0.8 nCPM
bergmann glia: 0.7 nCPM
choroid plexus epithelial cells: 0.7 nCPM
brain inhibitory neurons: 0.6 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.4 nTPM
white matter: 0.3 nTPM
amygdala: 0.2 nTPM
basal ganglia: 0.2 nTPM
cerebellum: 0.2 nTPM
hippocampal formation: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -3.39
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC35G5 as an antibody target. Whether an autoantibody or antibody against SLC35G5 could matter depends on whether native SLC35G5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC35G5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC35G5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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