Seroatlas · Human Serome Atlas

SLC35G4

Solute carrier family 35 member G4

Also known as: AMAC1L1, S35G4_HUMAN, SLC35G4P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0C7Q5
Gene
SLC35G4
Ensembl
ENSG00000236396
Chromosome
18
Canonical length
338 aa
Protein class
Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

338 residues, UniProt reviewed canonical sequence.

>P0C7Q5|SLC35G4
     1  MAGSHPYFNL PDSTHPSPPS TPPSLHWHQR CQPSDATNGL LVALLGGGLP AGFVGPLSRM
    61  AYQASNLPSL ELVICRCLFH LPIALLLKLR GDPLLGPPDI RGRTCFCALL NVLNIGCAYS
   121  AVQVVPTGNA ATVRKHSSTV CSAILTLCLE SQVLSGYDWC GLLGSILGLI IIVGPGLWTL
   181  QEGTTGVYTG LGYVQAFLGG LALSLGLLVY RSLHFPSCLP TVAFLSGLVG LLGSVPGLFV
   241  LQSPVLPSDL LSWSCVGAVG ILTLVSFTCV GYAVTKAHPA LVCAVLHSEV VMALILQYFM
   301  LHETVAPSDI MGAGVVLGSI AIITARNLIC ERTGKVEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC35G4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
0.2 nTPM

Expression across tissuesHPA

Tissue

  • testis: 0.2 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • early spermatids: 0.8 nCPM
  • podocytes: 0.3 nCPM
  • early primary spermatocytes: 0.2 nCPM
  • late primary spermatocytes: 0.2 nCPM
  • distal convoluted tubule cells: 0.1 nCPM
  • late spermatids: 0.1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC35G4 as an antibody target. Whether an autoantibody or antibody against SLC35G4 could matter depends on whether native SLC35G4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC35G4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC35G4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC35G4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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