Seroatlas · Human Serome Atlas

SLC35G3

Solute carrier family 35 member G3

Also known as: AMAC1, FLJ40154, S35G3_HUMAN, TMEM21A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N808
Gene: SLC35G3
Ensembl: ENSG00000164729
Chromosome: 17
Canonical length: 338 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

338 residues, UniProt reviewed canonical sequence.

>Q8N808|SLC35G3
     1  MAGSHPYFNQ PDSTHPSPPS APPSLRWYQR CQPSDATSGL LVALLGGGLP AGFVGPLSRM
    61  AYQASNLPSL ELLIWRCLFH LPIALLLKLR GDPLLGTPDI RSRAFFCALL NILSIGCAYS
   121  AVQVVPAGNA ATVRKGSSTV CSAVLTLCLE SQGLSGYDWC GLLGCILGLI IIVGPGLWTL
   181  QEGTTGVYTA LGYVEAFLGG LALSLRLLVY RSLHFPPCLP TVAFLSGLVG LLGSVPGLFV
   241  LQAPVLPSDL LSWSCVGAVG ILALVSFTCV GYAVTKAHPA LVCAVLHSEV VVALILQYYM
   301  LHETVAPSDI VAAGVVLGSI AIITAQNLSC ERTGRVEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC35G3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 9
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 2.4 nTPM

Expression across tissuesHPA

Tissue

testis: 2.4 nTPM
skeletal muscle: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

late primary spermatocytes: 24 nCPM
early spermatids: 20 nCPM
late spermatids: 2.6 nCPM
myonuclei: 1.3 nCPM
cardiomyocytes: 0.8 nCPM
early primary spermatocytes: 0.7 nCPM

Immune cell

naive CD8 T-cell: 0.7 nTPM
naive CD4 T-cell: 0.2 nTPM
T-reg: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -0.53
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC35G3 as an antibody target. Whether an autoantibody or antibody against SLC35G3 could matter depends on whether native SLC35G3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC35G3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC35G3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...