Seroatlas · Human Serome Atlas

SLC35G2

Solute carrier family 35 member G2

Also known as: DKFZp564K2464, MGC3295, S35G2_HUMAN, TMEM22

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TBE7
Gene: SLC35G2
Ensembl: ENSG00000168917
Chromosome: 3
Canonical length: 412 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Plasma membrane

OverviewNCBI Gene

Located in Golgi apparatus; plasma membrane; and synaptic vesicle membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

412 residues, UniProt reviewed canonical sequence.

>Q8TBE7|SLC35G2
     1  MDTSPSRKYP VKKRVKIHPN TVMVKYTSHY PQPGDDGYEE INEGYGNFME ENPKKGLLSE
    61  MKKKGRAFFG TMDTLPPPTE DPMINEIGQF QSFAEKNIFQ SRKMWIVLFG SALAHGCVAL
   121  ITRLVSDRSK VPSLELIFIR SVFQVLSVLV VCYYQEAPFG PSGYRLRLFF YGVCNVISIT
   181  CAYTSFSIVP PSNGTTMWRA TTTVFSAILA FLLVDEKMAY VDMATVVCSI LGVCLVMIPN
   241  IVDEDNSLLN AWKEAFGYTM TVMAGLTTAL SMIVYRSIKE KISMWTALFT FGWTGTIWGI
   301  STMFILQEPI IPLDGETWSY LIAICVCSTA AFLGVYYALD KFHPALVSTV QHLEIVVAMV
   361  LQLLVLHIFP SIYDVFGGVI IMISVFVLAG YKLYWRNLRK QDYQEILDSP IK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC35G2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 10
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

pituitary gland: 19 nTPM
cerebellum: 18 nTPM
hypothalamus: 17 nTPM
adrenal gland: 15 nTPM
adipose tissue: 14 nTPM
basal ganglia: 14 nTPM

Single-cell type

sertoli cells: 107 nCPM
adipocytes: 99 nCPM
lactotrophs: 98 nCPM
late primary spermatocytes: 90 nCPM
astrocytes: 88 nCPM
gonadotrophs: 81 nCPM

Immune cell

memory CD8 T-cell: 1 nTPM
naive CD8 T-cell: 0.7 nTPM
gdT-cell: 0.4 nTPM
MAIT T-cell: 0.1 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM

Brain region

pons: 33 nTPM
midbrain: 29 nTPM
hypothalamus: 28 nTPM
cerebellum: 24 nTPM
medulla oblongata: 24 nTPM
spinal cord: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.85
gnomAD pLI: 0.04
gnomAD missense Z: 0.42
DepMap mean gene effect: 0.17
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC35G2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RAB37

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC35G2 as an antibody target. Whether an autoantibody or antibody against SLC35G2 could matter depends on whether native SLC35G2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC35G2 is annotated at the cell surface, where native SLC35G2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC35G2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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