Seroatlas · Human Serome Atlas

SLC35F5

Solute carrier family 35 member F5

Also known as: FLJ22004, S35F5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WV83
Gene: SLC35F5
Ensembl: ENSG00000115084
Chromosome: 2
Canonical length: 523 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Plasma membrane

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

523 residues, UniProt reviewed canonical sequence.

>Q8WV83|SLC35F5
     1  MVPPRRHRGA GRPGVLSSSP PFRLRSAKFS GIALEDLRRA LKTRLQMVCV FVMNRMNSQN
    61  SGFTQRRRMA LGIVILLLVD VIWVASSELT SYVFTQYNKP FFSTFAKTSM FVLYLLGFII
   121  WKPWRQQCTR GLRGKHAAFF ADAEGYFAAC TTDTTMNSSL SEPLYVPVKF HDLPSEKPES
   181  TNIDTEKTPK KSRVRFSNIM EIRQLPSSHA LEAKLSRMSY PVKEQESILK TVGKLTATQV
   241  AKISFFFCFV WFLANLSYQE ALSDTQVAIV NILSSTSGLF TLILAAVFPS NSGDRFTLSK
   301  LLAVILSIGG VVLVNLAGSE KPAGRDTVGS IWSLAGAMLY AVYIVMIKRK VDREDKLDIP
   361  MFFGFVGLFN LLLLWPGFFL LHYTGFEDFE FPNKVVLMCI IINGLIGTVL SEFLWLWGCF
   421  LTSSLIGTLA LSLTIPLSII ADMCMQKVQF SWLFFAGAIP VFFSFFIVTL LCHYNNWDPV
   481  MVGIRRIFAF ICRKHRIQRV PEDSEQCESL ISMHSVSQED GAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC35F5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 10
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 22 nTPM
adrenal gland: 22 nTPM
choroid plexus: 21 nTPM
skin: 19 nTPM
kidney: 17 nTPM
parathyroid gland: 16 nTPM

Single-cell type

choroid plexus epithelial cells: 415 nCPM
adrenal cortex cells: 317 nCPM
distal convoluted tubule cells: 247 nCPM
parietal cells: 232 nCPM
ocular epithelial cells: 205 nCPM
podocytes: 194 nCPM

Immune cell

basophil: 2.7 nTPM
neutrophil: 2 nTPM
non-classical monocyte: 1.2 nTPM
naive B-cell: 1.1 nTPM
NK-cell: 1 nTPM
T-reg: 0.9 nTPM

Brain region

choroid plexus: 79 nTPM
cerebellum: 37 nTPM
white matter: 36 nTPM
medulla oblongata: 27 nTPM
hypothalamus: 26 nTPM
hippocampal formation: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.83
gnomAD pLI: 0
gnomAD missense Z: 0.98
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Multidrug transporter EmrE superfamily

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC35F5 as an antibody target. Whether an autoantibody or antibody against SLC35F5 could matter depends on whether native SLC35F5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC35F5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC35F5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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