Seroatlas · Human Serome Atlas

SLC35F4

Solute carrier family 35 member F4

Also known as: C14orf36, FLJ37712, S35F4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A4IF30
Gene: SLC35F4
Ensembl: ENSG00000151812
Chromosome: 14
Canonical length: 521 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

521 residues, UniProt reviewed canonical sequence.

>A4IF30|SLC35F4
     1  MDELLLDLFH KLTSGRQLAA GNGLCGISHK EQEVWKPGHN ILVKMRKEDK SLVWLIHSTL
    61  ARYTQVTNFL GTSRSSVTRC KPGANCPSSH SGISRQLSPL SVTEDSSAPI LELQNQGSSG
   121  VCGHRVERQN RSADDGTQTH SENSSQENRI KARCLSCTSM VLKGIWGLLI ILSVSSSWVG
   181  TTQIVKITYK NFYCPFFMTW FSTNWNIMFF PVYYSGHLAT AQEKQSPMKK FRECSRIFGE
   241  DGLTLKLFLK RTAPFSILWT LTNYLYLLAL KKLTATDVSA LFCCNKAFVF LLSWIVLKDR
   301  FMGVRIVAAI MAITGIVMMA YADNFHADSI IGVAFAVGSA STSALYKVLF KMFLGSANFG
   361  EAAHFVSTLG FFNLIFISFT PVILYFTKVE HWSSFAALPW GCLCGMAGLW LAFNILVNVG
   421  VVLTYPILIS IGTVLSVPGN AAVDLLKQEV IFNVVRLAAT IIICIGFLLM LLPEEWDEIT
   481  LRFINSLKEK KSEEHVDDVT DPSIHLRGRG RANGTVSIPL A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC35F4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 10
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 13 nTPM
retina: 6 nTPM
seminal vesicle: 3.3 nTPM
basal ganglia: 2.4 nTPM
hypothalamus: 1.8 nTPM
prostate: 1.2 nTPM

Single-cell type

rod photoreceptor cells: 475 nCPM
pancreatic islet cells: 240 nCPM
brain inhibitory neurons: 212 nCPM
brain excitatory neurons: 207 nCPM
retinal bipolar cells: 198 nCPM
peritubular myoid cells: 144 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 12 nTPM
spinal cord: 6.3 nTPM
hypothalamus: 4.8 nTPM
pons: 3.9 nTPM
medulla oblongata: 3.8 nTPM
midbrain: 3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.67
gnomAD pLI: 0.01
gnomAD missense Z: 0.36

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC35F4 as an antibody target. Whether an autoantibody or antibody against SLC35F4 could matter depends on whether native SLC35F4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC35F4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC35F4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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