Seroatlas · Human Serome Atlas

SLC35F3

Solute carrier family 35 member F3

Also known as: FLJ37712, S35F3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IY50
Gene: SLC35F3
Ensembl: ENSG00000183780
Chromosome: 1
Canonical length: 421 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Nucleoli,Golgi apparatus

OverviewNCBI Gene

Involved in thiamine transport. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

421 residues, UniProt reviewed canonical sequence.

>Q8IY50|SLC35F3
     1  MKKHSARVAP LSACNSPVLT LTKVEGEERP RDSPGPAEAQ APAGVEAGGR ASRRCWTCSR
    61  AQLKKIFWGV AVVLCVCSSW AGSTQLAKLT FRKFDAPFTL TWFATNWNFL FFPLYYVGHV
   121  CKSTEKQSVK QRYRECCRFF GDNGLTLKVF FTKAAPFGVL WTLTNYLYLH AIKKINTTDV
   181  SVLFCCNKAF VFLLSWIVLR DRFMGVRIVA AILAIAGIVM MTYADGFHSH SVIGIALVVA
   241  SASMSALYKV LFKLLLGSAK FGEAALFLSI LGVFNILFIT CIPIILYFTK VEYWSSFDDI
   301  PWGNLCGFSV LLLTFNIVLN FGIAVTYPTL MSLGIVLSIP VNAVIDHYTS QIVFNGVRVI
   361  AIIIIGLGFL LLLLPEEWDV WLIKLLTRLK VRKKEEPAEG AADLSSGPQS KNRRARPSFA
   421  R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC35F3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 9
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 16 nTPM
basal ganglia: 9.3 nTPM
cerebral cortex: 8.5 nTPM
spinal cord: 4.9 nTPM
hippocampal formation: 4.8 nTPM
hypothalamus: 4.1 nTPM

Single-cell type

brain inhibitory neurons: 1,145 nCPM
pancreatic islet cells: 553 nCPM
brain excitatory neurons: 451 nCPM
oligodendrocyte progenitor cells: 362 nCPM
other brain neurons: 345 nCPM
adrenal medulla cells: 298 nCPM

Immune cell

plasmacytoid DC: 3.5 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

basal ganglia: 46 nTPM
cerebral cortex: 42 nTPM
white matter: 29 nTPM
cerebellum: 29 nTPM
hippocampal formation: 20 nTPM
hypothalamus: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.54
gnomAD pLI: 0.1
gnomAD missense Z: 1.71
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

thiamine transport

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC35F3 as an antibody target. Whether an autoantibody or antibody against SLC35F3 could matter depends on whether native SLC35F3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC35F3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC35F3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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