Seroatlas · Human Serome Atlas

SLC35E4

Solute carrier family 35 member E4

Also known as: S35E4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ICL7
Gene: SLC35E4
Ensembl: ENSG00000100036
Chromosome: 22
Canonical length: 350 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to enable antiporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

350 residues, UniProt reviewed canonical sequence.

>Q6ICL7|SLC35E4
     1  MCRCPPEHHD GRMTSAEVGA AAGGAQAAGP PEWPPGSPQA LRQPGRARVA MAALVWLLAG
    61  ASMSSLNKWI FTVHGFGRPL LLSALHMLVA ALACHRGARR PMPGGTRCRV LLLSLTFGTS
   121  MACGNVGLRA VPLDLAQLVT TTTPLFTLAL SALLLGRRHH PLQLAAMGPL CLGAACSLAG
   181  EFRTPPTGCG FLLAATCLRG LKSVQQSALL QEERLDAVTL LYATSLPSFC LLAGAALVLE
   241  AGVAPPPTAG DSRLWACILL SCLLSVLYNL ASFSLLALTS ALTVHVLGNL TVVGNLILSR
   301  LLFGSRLSAL SYVGIALTLS GMFLYHNCEF VASWAARRGL WRRDQPSKGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC35E4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

testis: 22 nTPM
skeletal muscle: 10 nTPM
skin: 5.3 nTPM
cerebral cortex: 4.7 nTPM
basal ganglia: 3.9 nTPM
hypothalamus: 3.7 nTPM

Single-cell type

myonuclei: 38 nCPM
alveolar cells type 1: 34 nCPM
müller glia: 31 nCPM
oligodendrocytes: 30 nCPM
lymphatic endothelial cells: 30 nCPM
respiratory ciliated cells: 29 nCPM

Immune cell

myeloid DC: 1.1 nTPM
memory CD8 T-cell: 0.9 nTPM
intermediate monocyte: 0.8 nTPM
non-classical monocyte: 0.7 nTPM
T-reg: 0.7 nTPM
basophil: 0.6 nTPM

Brain region

white matter: 21 nTPM
cerebral cortex: 20 nTPM
basal ganglia: 17 nTPM
medulla oblongata: 16 nTPM
thalamus: 16 nTPM
pons: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0.02
gnomAD missense Z: 0.99
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

transmembrane transport

Molecular functions

antiporter activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC35E4 as an antibody target. Whether an autoantibody or antibody against SLC35E4 could matter depends on whether native SLC35E4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC35E4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC35E4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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