Seroatlas · Human Serome Atlas

SLC35E3

Solute carrier family 35 member E3

Also known as: BLOV1, S35E3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z769
Gene: SLC35E3
Ensembl: ENSG00000175782
Chromosome: 12
Canonical length: 313 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to enable antiporter activity and nucleotide-sugar transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

313 residues, UniProt reviewed canonical sequence.

>Q7Z769|SLC35E3
     1  MALLVDRVRG HWRIAAGLLF NLLVSICIVF LNKWIYVYHG FPNMSLTLVH FVVTWLGLYI
    61  CQKLDIFAPK SLPPSRLLLL ALSFCGFVVF TNLSLQNNTI GTYQLAKAMT TPVIIAIQTF
   121  CYQKTFSTRI QLTLIPITLG VILNSYYDVK FNFLGMVFAA LGVLVTSLYQ VWVGAKQHEL
   181  QVNSMQLLYY QAPMSSAMLL VAVPFFEPVF GEGGIFGPWS VSALLMVLLS GVIAFMVNLS
   241  IYWIIGNTSP VTYNMFGHFK FCITLFGGYV LFKDPLSINQ ALGILCTLFG ILAYTHFKLS
   301  EQEGSRSKLA QRP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC35E3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 9
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 1.3 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 1.3 nTPM
skin: 1.3 nTPM
retina: 1.2 nTPM
cerebellum: 1.1 nTPM
adrenal gland: 0.9 nTPM
spinal cord: 0.9 nTPM

Single-cell type

neutrophils: 198 nCPM
retinal ganglion cells: 97 nCPM
oligodendrocytes: 96 nCPM
prostatic glandular cells: 74 nCPM
retinal amacrine cells: 72 nCPM
proximal tubule cells: 66 nCPM

Immune cell

basophil: 1.9 nTPM
neutrophil: 1.8 nTPM
naive B-cell: 0.7 nTPM
NK-cell: 0.5 nTPM
plasmacytoid DC: 0.5 nTPM
classical monocyte: 0.4 nTPM

Brain region

cerebellum: 12 nTPM
white matter: 12 nTPM
pons: 9.9 nTPM
cerebral cortex: 9.7 nTPM
thalamus: 9.5 nTPM
medulla oblongata: 9.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.32
gnomAD pLI: 0
gnomAD missense Z: 0.12
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

transmembrane transport

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC35E3 as an antibody target. Whether an autoantibody or antibody against SLC35E3 could matter depends on whether native SLC35E3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC35E3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC35E3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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