Seroatlas · Human Serome Atlas

SLC35E2B

Solute carrier family 35 member E2B

Also known as: S352B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0CK96
Gene: SLC35E2B
Ensembl: ENSG00000189339
Chromosome: 1
Canonical length: 405 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable antiporter activity. Predicted to be involved in transmembrane transport. Predicted to act upstream of or within blastocyst hatching. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

405 residues, UniProt reviewed canonical sequence.

>P0CK96|SLC35E2B
     1  MSSSVKTPAL EELVPGSEEK PKGRSPLSWG SLFGHRSEKI VFAKSDGGTD ENVLTVTITE
    61  TTVIESDLGV WSSRALLYLT LWFFFSFCTL FLNKYILSLL GGEPSMLGAV QMLSTTVIGC
   121  VKTLVPCCLY QHKARLSYPP NFLMTMLFVG LMRFATVVLG LVSLKNVAVS FAETVKSSAP
   181  IFTVIMSRMI LGEYTGLLVN LSLIPVMGGL ALCTATEISF NVLGFSAALS TNIMDCLQNV
   241  FSKKLLSGDK YRFSAPELQF YTSAAAVAML VPARVFFTDV PVIGRSGKSF SYNQDVVLLL
   301  LTDGVLFHLQ SVTAYALMGK ISPVTFSVAS TVKHALSIWL SVIVFGNKIT SLSAVGTALV
   361  TVGVLLYNKA RQHQQEALQS LAAATGRAPD DTVEPLLPQD PRQHP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC35E2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 9
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 47 nTPM
pituitary gland: 41 nTPM
retina: 40 nTPM
spleen: 38 nTPM
ovary: 38 nTPM
cervix: 35 nTPM

Single-cell type

corticotrophs: 79 nCPM
myonuclei: 48 nCPM
rod photoreceptor cells: 47 nCPM
somatotrophs: 47 nCPM
cone photoreceptor cells: 44 nCPM
neutrophils: 43 nCPM

Immune cell

plasmacytoid DC: 8.9 nTPM
memory CD8 T-cell: 8.5 nTPM
MAIT T-cell: 8.2 nTPM
gdT-cell: 7.8 nTPM
naive CD4 T-cell: 7.4 nTPM
memory CD4 T-cell: 6.6 nTPM

Brain region

hippocampal formation: 86 nTPM
amygdala: 84 nTPM
cerebral cortex: 83 nTPM
basal ganglia: 72 nTPM
white matter: 69 nTPM
choroid plexus: 68 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.96
gnomAD pLI: 0
gnomAD missense Z: 0.99
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

antiporter activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC35E2B as an antibody target. Whether an autoantibody or antibody against SLC35E2B could matter depends on whether native SLC35E2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC35E2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC35E2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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