Seroatlas · Human Serome Atlas

SLC35E2A

Solute carrier family 35 member E2A

Also known as: S35E2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0CK97
Gene: SLC35E2A
Canonical length: 266 aa

OverviewNCBI Gene

No narrative summary is available for SLC35E2A in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

266 residues, UniProt reviewed canonical sequence.

>P0CK97|SLC35E2A
     1  MSSSVKTPAL EELVPGSEEK PKGRSPLSWG SLFGHRSEKI VFAKSDGGTD ENVLTVTITE
    61  TTVIESDLGV WSSRALLYLT LWFFFSFCTL FLNKYILSLL GGEPSMLGAV QMLSTTVIGC
   121  VKTLVPCCLY QHKARLSYPP NFLMTMLFVG LMRFATVVLG LVSLKNVAVS FAETVKSSAP
   181  IFTVIMSRMI LGEYTGRPSD REEREELQLQ PGRGAAASDR RSPVPPSERH GVRPHGENLP
   241  GDFQVPQALH RVALSMALPC PMLPAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC35E2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.58

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

transmembrane transport

Molecular functions

antiporter activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC35E2A as an antibody target. Whether an autoantibody or antibody against SLC35E2A could matter depends on whether native SLC35E2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC35E2A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC35E2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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