Seroatlas · Human Serome Atlas

SLC35E1

Solute carrier family 35 member E1

Also known as: FLJ14251, S35E1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96K37
Gene: SLC35E1
Ensembl: ENSG00000127526
Chromosome: 19
Canonical length: 410 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Golgi apparatus

OverviewNCBI Gene

Predicted to enable antiporter activity. Predicted to be involved in transmembrane transport. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

410 residues, UniProt reviewed canonical sequence.

>Q96K37|SLC35E1
     1  MAAAAVGAGH GAGGPGAASS SGGAREGARV AALCLLWYAL SAGGNVVNKV ILSAFPFPVT
    61  VSLCHILALC AGLPPLLRAW RVPPAPPVSG PGPSPHPSSG PLLPPRFYPR YVLPLAFGKY
   121  FASVSAHVSI WKVPVSYAHT VKATMPIWVV LLSRIIMKEK QSTKVYLSLI PIISGVLLAT
   181  VTELSFDMWG LVSALAATLC FSLQNIFSKK VLRDSRIHHL RLLNILGCHA VFFMIPTWVL
   241  VDLSAFLVSS DLTYVYQWPW TLLLLAVSGF CNFAQNVIAF SILNLVSPLS YSVANATKRI
   301  MVITVSLIML RNPVTSTNVL GMMTAILGVF LYNKTKYDAN QQARKHLLPV TTADLSSKER
   361  HRSPLEKPHN GLLFPQHGDY QYGRNNILTD HFQYSRQSYP NSYSLNRYDV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC35E1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 9
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

pancreas: 21 nTPM
skeletal muscle: 18 nTPM
salivary gland: 15 nTPM
parathyroid gland: 14 nTPM
stomach: 13 nTPM
tongue: 13 nTPM

Single-cell type

platelets: 9.8 nCPM
innate lymphoid cells: 5.4 nCPM
prostatic glandular cells: 5.1 nCPM
thymic myoid cells: 4.1 nCPM
retinal ganglion cells: 3.9 nCPM
parietal cells: 3.5 nCPM

Immune cell

eosinophil: 3.2 nTPM
memory B-cell: 2.2 nTPM
non-classical monocyte: 2 nTPM
basophil: 1.8 nTPM
MAIT T-cell: 1.8 nTPM
NK-cell: 1.8 nTPM

Brain region

thalamus: 35 nTPM
cerebral cortex: 29 nTPM
choroid plexus: 29 nTPM
midbrain: 29 nTPM
amygdala: 28 nTPM
pons: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.65
gnomAD pLI: 0.13
gnomAD missense Z: 1.48
DepMap mean gene effect: -0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

transmembrane transport

Molecular functions

antiporter activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC35E1 as an antibody target. Whether an autoantibody or antibody against SLC35E1 could matter depends on whether native SLC35E1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC35E1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC35E1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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