Seroatlas · Human Serome Atlas

SLC35D2

Nucleotide sugar transporter SLC35D2

Also known as: S35D2_HUMAN, SQV7L, UGTrel8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q76EJ3
Gene: SLC35D2
Ensembl: ENSG00000130958
Chromosome: 9
Canonical length: 337 aa
Protein class: Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location: Golgi apparatus

OverviewNCBI Gene

Nucleotide sugars, which are synthesized in the cytosol or the nucleus, are high-energy donor substrates for glycosyltransferases located in the lumen of the endoplasmic reticulum and Golgi apparatus. Translocation of nucleotide sugars from the cytosol into the lumen compartment is mediated by specific nucleotide sugar transporters, such as SLC35D2 (Suda et al., 2004 [PubMed 15082721]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

337 residues, UniProt reviewed canonical sequence.

>Q76EJ3|SLC35D2
     1  MTAGGQAEAE GAGGEPGAAR LPSRVARLLS ALFYGTCSFL IVLVNKALLT TYGFPSPIFL
    61  GIGQMAATIM ILYVSKLNKI IHFPDFDKKI PVKLFPLPLL YVGNHISGLS STSKLSLPMF
   121  TVLRKFTIPL TLLLETIILG KQYSLNIILS VFAIILGAFI AAGSDLAFNL EGYIFVFLND
   181  IFTAANGVYT KQKMDPKELG KYGVLFYNAC FMIIPTLIIS VSTGDLQQAT EFNQWKNVVF
   241  ILQFLLSCFL GFLLMYSTVL CSYYNSALTT AVVGAIKNVS VAYIGILIGG DYIFSLLNFV
   301  GLNICMAGGL RYSFLTLSSQ LKPKPVGEEN ICLDLKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC35D2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 62 nTPM

Expression across tissuesHPA

Tissue

small intestine: 62 nTPM
duodenum: 61 nTPM
liver: 53 nTPM
colon: 46 nTPM
rectum: 44 nTPM
stomach: 41 nTPM

Single-cell type

oligodendrocytes: 144 nCPM
microglia: 67 nCPM
proximal tubule cells: 62 nCPM
hepatocytes: 52 nCPM
bergmann glia: 31 nCPM
distal convoluted tubule cells: 28 nCPM

Immune cell

T-reg: 3.9 nTPM
memory CD8 T-cell: 2.9 nTPM
memory CD4 T-cell: 2.1 nTPM
non-classical monocyte: 2.1 nTPM
NK-cell: 1.8 nTPM
MAIT T-cell: 1.7 nTPM

Brain region

white matter: 41 nTPM
medulla oblongata: 39 nTPM
pons: 31 nTPM
thalamus: 28 nTPM
basal ganglia: 27 nTPM
midbrain: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.6
gnomAD pLI: 0
gnomAD missense Z: 0.49
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC35D2 as an antibody target. Whether an autoantibody or antibody against SLC35D2 could matter depends on whether native SLC35D2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC35D2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC35D2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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