Seroatlas · Human Serome Atlas

SLC35B4

Nucleotide sugar transporter SLC35B4

Also known as: FLJ14697, S35B4_HUMAN, YEA4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q969S0
Gene: SLC35B4
Ensembl: ENSG00000205060
Chromosome: 7
Canonical length: 331 aa
Protein class: Metabolic proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Glycosyltransferases, such as SLC35B4, transport nucleotide sugars from the cytoplasm where they are synthesized, to the Golgi apparatus where they are utilized in the synthesis of glycoproteins, glycolipids, and proteoglycans (Ashikov et al., 2005 [PubMed 15911612]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

331 residues, UniProt reviewed canonical sequence.

>Q969S0|SLC35B4
     1  MRPALAVGLV FAGCCSNVIF LELLARKHPG CGNIVTFAQF LFIAVEGFLF EADLGRKPPA
    61  IPIRYYAIMV TMFFTVSVVN NYALNLNIAM PLHMIFRSGS LIANMILGII ILKKRYSIFK
   121  YTSIALVSVG IFICTFMSAK QVTSQSSLSE NDGFQAFVWW LLGIGALTFA LLMSARMGIF
   181  QETLYKRFGK HSKEALFYNH ALPLPGFVFL ASDIYDHAVL FNKSELYEIP VIGVTLPIMW
   241  FYLLMNIITQ YVCIRGVFIL TTECASLTVT LVVTLRKFVS LIFSILYFQN PFTLWHWLGT
   301  LFVFIGTLMY TEVWNNLGTT KSEPQKDSKK N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC35B4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 10
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 13 nTPM
retina: 11 nTPM
placenta: 11 nTPM
cerebral cortex: 10 nTPM
kidney: 9.8 nTPM
liver: 8 nTPM

Single-cell type

distal convoluted tubule cells: 150 nCPM
cytotrophoblasts: 140 nCPM
syncytiotrophoblasts: 122 nCPM
migrating cytotrophoblasts: 93 nCPM
renal connecting tubule cells: 93 nCPM
megakaryocytes: 56 nCPM

Immune cell

myeloid DC: 3.1 nTPM
MAIT T-cell: 2.5 nTPM
naive CD8 T-cell: 2.2 nTPM
intermediate monocyte: 2.1 nTPM
memory CD8 T-cell: 2.1 nTPM
plasmacytoid DC: 2.1 nTPM

Brain region

hypothalamus: 27 nTPM
cerebellum: 26 nTPM
midbrain: 24 nTPM
basal ganglia: 24 nTPM
thalamus: 24 nTPM
medulla oblongata: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.96
gnomAD pLI: 0
gnomAD missense Z: 1.2
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of gluconeogenesis
UDP-N-acetylglucosamine transmembrane transport
UDP-xylose transmembrane transport

Molecular functions

UDP-N-acetylglucosamine transmembrane transporter activity
UDP-xylose transmembrane transporter activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC35B4 as an antibody target. Whether an autoantibody or antibody against SLC35B4 could matter depends on whether native SLC35B4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC35B4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC35B4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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