Seroatlas · Human Serome Atlas

SLC35B3

Adenosine 3'-phospho 5'-phosphosulfate transporter 2

Also known as: C6orf196, CGI-19, dJ453H5.1, PAPST2, S35B3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H1N7
Gene: SLC35B3
Ensembl: ENSG00000124786
Chromosome: 6
Canonical length: 401 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene is a member of the solute carrier family. The encoded protein is involved in the transport of 3-prime phosphoadenosine 5-prime phosphosulfate (PAPS) from the nucleus or the cytosol to the Golgi lumen. This gene has been reported to be expressed preferentially in the human colon tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Canonical amino-acid sequenceUniProt

401 residues, UniProt reviewed canonical sequence.

>Q9H1N7|SLC35B3
     1  MDLTQQAKDI QNITVQETNK NNSESIECSK ITMDLKFNNS RKYISITVPS KTQTMSPHIK
    61  SVDDVVVLGM NLSKFNKLTQ FFICVAGVFV FYLIYGYLQE LIFSVEGFKS CGWYLTLVQF
   121  AFYSIFGLIE LQLIQDKRRR IPGKTYMIIA FLTVGTMGLS NTSLGYLNYP TQVIFKCCKL
   181  IPVMLGGVFI QGKRYNVADV SAAICMSLGL IWFTLADSTT APNFNLTGVV LISLALCADA
   241  VIGNVQEKAM KLHNASNSEM VLYSYSIGFV YILLGLTCTS GLGPAVTFCA KNPVRTYGYA
   301  FLFSLTGYFG ISFVLALIKI FGALIAVTVT TGRKAMTIVL SFIFFAKPFT FQYVWSGLLV
   361  VLGIFLNVYS KNMDKIRLPS LYDLINKSVE ARKSRTLAQT V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC35B3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 10
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 41 nTPM

Expression across tissuesHPA

Tissue

epididymis: 41 nTPM
rectum: 23 nTPM
colon: 23 nTPM
liver: 22 nTPM
thyroid gland: 17 nTPM
pancreas: 17 nTPM

Single-cell type

epididymal principal cells: 139 nCPM
renal collecting duct principal cells: 104 nCPM
epididymal efferent duct absorptive cells: 96 nCPM
goblet cells: 88 nCPM
breast lactating cells: 81 nCPM
gastric chief cells: 72 nCPM

Immune cell

NK-cell: 11 nTPM
naive CD4 T-cell: 7 nTPM
T-reg: 7 nTPM
MAIT T-cell: 6.9 nTPM
memory CD8 T-cell: 6.6 nTPM
gdT-cell: 6.3 nTPM

Brain region

white matter: 12 nTPM
basal ganglia: 9.2 nTPM
choroid plexus: 9.2 nTPM
pons: 8.8 nTPM
medulla oblongata: 8.7 nTPM
thalamus: 8.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.4
gnomAD pLI: 0
gnomAD missense Z: 0.5
DepMap mean gene effect: 0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC35B3 as an antibody target. Whether an autoantibody or antibody against SLC35B3 could matter depends on whether native SLC35B3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC35B3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC35B3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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