Seroatlas · Human Serome Atlas

SLC35A5

UDP-sugar transporter protein SLC35A5

Also known as: FLJ20730, S35A5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BS91
Gene: SLC35A5
Ensembl: ENSG00000138459
Chromosome: 3
Canonical length: 424 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Golgi apparatus
Quaternary structure: Homooligomer

OverviewNCBI Gene

This gene encodes a transmembrane protein which belongs to subfamily 35A of the solute carrier superfamily. The encoded protein is a nucleoside-sugar transporter. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

Canonical amino-acid sequenceUniProt

424 residues, UniProt reviewed canonical sequence.

>Q9BS91|SLC35A5
     1  MEKQCCSHPV ICSLSTMYTF LLGAIFIALS SSRILLVKYS ANEENKYDYL PTTVNVCSEL
    61  VKLVFCVLVS FCVIKKDHQS RNLKYASWKE FSDFMKWSIP AFLYFLDNLI VFYVLSYLQP
   121  AMAVIFSNFS IITTALLFRI VLKRRLNWIQ WASLLTLFLS IVALTAGTKT LQHNLAGRGF
   181  HHDAFFSPSN SCLLFRSECP RKDNCTAKEW TFPEAKWNTT ARVFSHIRLG MGHVLIIVQC
   241  FISSMANIYN EKILKEGNQL TESIFIQNSK LYFFGILFNG LTLGLQRSNR DQIKNCGFFY
   301  GHSAFSVALI FVTAFQGLSV AFILKFLDNM FHVLMAQVTT VIITTVSVLV FDFRPSLEFF
   361  LEAPSVLLSI FIYNASKPQV PEYAPRQERI RDLSGNLWER SSGDGEELER LTKPKSDESD
   421  EDTF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC35A5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 10
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 34 nTPM
thyroid gland: 24 nTPM
cerebral cortex: 23 nTPM
retina: 20 nTPM
liver: 20 nTPM
midbrain: 19 nTPM

Single-cell type

early spermatids: 287 nCPM
neutrophils: 58 nCPM
cytotrophoblasts: 49 nCPM
kupffer cells: 48 nCPM
oligodendrocytes: 47 nCPM
late primary spermatocytes: 45 nCPM

Immune cell

non-classical monocyte: 28 nTPM
intermediate monocyte: 26 nTPM
eosinophil: 21 nTPM
myeloid DC: 20 nTPM
classical monocyte: 17 nTPM
basophil: 15 nTPM

Brain region

white matter: 51 nTPM
medulla oblongata: 40 nTPM
basal ganglia: 38 nTPM
spinal cord: 38 nTPM
cerebellum: 36 nTPM
pons: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.15
gnomAD pLI: 0
gnomAD missense Z: -0.07
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

transmembrane transport

Molecular functions

Cellular components

Golgi membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC35A5 as an antibody target. Whether an autoantibody or antibody against SLC35A5 could matter depends on whether native SLC35A5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC35A5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC35A5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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