Seroatlas · Human Serome Atlas

SLC35A4

Probable UDP-sugar transporter protein SLC35A4

Also known as: S35A4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96G79
Gene: SLC35A4
Ensembl: ENSG00000176087
Chromosome: 5
Canonical length: 324 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Endoplasmic reticulum,Centrosome

OverviewNCBI Gene

Predicted to enable transmembrane transporter activity. Involved in positive regulation of cellular respiration and positive regulation of translation in response to stress. Located in Golgi membrane and mitochondrial inner membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

324 residues, UniProt reviewed canonical sequence.

>Q96G79|SLC35A4
     1  MSVEDGGMPG LGRPRQARWT LMLLLSTAMY GAHAPLLALC HVDGRVPFRP SSAVLLTELT
    61  KLLLCAFSLL VGWQAWPQGP PPWRQAAPFA LSALLYGANN NLVIYLQRYM DPSTYQVLSN
   121  LKIGSTAVLY CLCLRHRLSV RQGLALLLLM AAGACYAAGG LQVPGNTLPS PPPAAAASPM
   181  PLHITPLGLL LLILYCLISG LSSVYTELLM KRQRLPLALQ NLFLYTFGVL LNLGLHAGGG
   241  SGPGLLEGFS GWAALVVLSQ ALNGLLMSAV MKHGSSITRL FVVSCSLVVN AVLSAVLLRL
   301  QLTAAFFLAT LLIGLAMRLY YGSR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC35A4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 8
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 123 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 123 nTPM
tongue: 88 nTPM
heart muscle: 68 nTPM
esophagus: 65 nTPM
adrenal gland: 63 nTPM
salivary gland: 62 nTPM

Single-cell type

late spermatids: 251 nCPM
esophageal apical cells: 69 nCPM
early spermatids: 64 nCPM
extravillous trophoblasts: 60 nCPM
late primary spermatocytes: 59 nCPM
esophageal suprabasal cells: 54 nCPM

Immune cell

total PBMC: 83 nTPM
intermediate monocyte: 83 nTPM
non-classical monocyte: 80 nTPM
myeloid DC: 76 nTPM
classical monocyte: 65 nTPM
NK-cell: 64 nTPM

Brain region

medulla oblongata: 45 nTPM
cerebellum: 43 nTPM
midbrain: 43 nTPM
pons: 42 nTPM
thalamus: 42 nTPM
spinal cord: 40 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.45
gnomAD pLI: 0
gnomAD missense Z: -0.15
DepMap mean gene effect: 0.15
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC35A4 as an antibody target. Whether an autoantibody or antibody against SLC35A4 could matter depends on whether native SLC35A4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC35A4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC35A4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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