Seroatlas · Human Serome Atlas

SLC35A1

CMP-sialic acid transporter

Also known as: CMPST, hCST, S35A1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P78382
Gene
SLC35A1
Ensembl
ENSG00000164414
Chromosome
6
Canonical length
337 aa
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The protein encoded by this gene is found in the membrane of the Golgi apparatus, where it transports nucleotide sugars into the Golgi. One such nucleotide sugar is CMP-sialic acid, which is imported into the Golgi by the encoded protein and subsequently glycosylated. Defects in this gene are a cause of congenital disorder of glycosylation type 2F (CDG2F). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009]

Canonical amino-acid sequenceUniProt

337 residues, UniProt reviewed canonical sequence.

>P78382|SLC35A1
     1  MAAPRDNVTL LFKLYCLAVM TLMAAVYTIA LRYTRTSDKE LYFSTTAVCI TEVIKLLLSV
    61  GILAKETGSL GRFKASLREN VLGSPKELLK LSVPSLVYAV QNNMAFLALS NLDAAVYQVT
   121  YQLKIPCTAL CTVLMLNRTL SKLQWVSVFM LCAGVTLVQW KPAQATKVVV EQNPLLGFGA
   181  IAIAVLCSGF AGVYFEKVLK SSDTSLWVRN IQMYLSGIIV TLAGVYLSDG AEIKEKGFFY
   241  GYTYYVWFVI FLASVGGLYT SVVVKYTDNI MKGFSAAAAI VLSTIASVML FGLQITLTFA
   301  LGTLLVCVSI YLYGLPRQDT TSIQQGETAS KERVIGV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC35A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
10
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
45 nTPM

Expression across tissuesHPA

Tissue

  • rectum: 45 nTPM
  • colon: 37 nTPM
  • lung: 35 nTPM
  • prostate: 35 nTPM
  • choroid plexus: 34 nTPM
  • liver: 31 nTPM

Single-cell type

  • goblet cells: 79 nCPM
  • prostatic glandular cells: 48 nCPM
  • oocytes: 46 nCPM
  • gastric progenitor cells: 36 nCPM
  • mucous neck cells: 36 nCPM
  • decidual stromal cells: 34 nCPM

Immune cell

  • classical monocyte: 52 nTPM
  • basophil: 51 nTPM
  • myeloid DC: 45 nTPM
  • non-classical monocyte: 43 nTPM
  • intermediate monocyte: 42 nTPM
  • total PBMC: 36 nTPM

Brain region

  • choroid plexus: 23 nTPM
  • cerebellum: 22 nTPM
  • cerebral cortex: 19 nTPM
  • hypothalamus: 17 nTPM
  • white matter: 16 nTPM
  • basal ganglia: 15 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC35A1.

Disease | AllUniProt

Conditions SLC35A1 is implicated in, by any mechanism.

  • Congenital disorder of glycosylation 2F (CDG2F) MIM:603585

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 125 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • SLC35A1-congenital disorder of glycosylation

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.46
gnomAD pLI
0.68
gnomAD missense Z
1.27
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC35A1 as an antibody target. Whether an autoantibody or antibody against SLC35A1 could matter depends on whether native SLC35A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC35A1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC35A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC35A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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