Seroatlas · Human Serome Atlas

SLC34A2

Sodium-dependent phosphate transport protein 2B

Also known as: NAPI-3B, NPT2B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95436
Gene
SLC34A2
Ensembl
ENSG00000157765
Chromosome
4
Canonical length
690 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a pH-sensitive sodium-dependent phosphate transporter. Phosphate uptake is increased at lower pH. Defects in this gene are a cause of pulmonary alveolar microlithiasis. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

690 residues, UniProt reviewed canonical sequence.

>O95436|SLC34A2
     1  MAPWPELGDA QPNPDKYLEG AAGQQPTAPD KSKETNKTDN TEAPVTKIEL LPSYSTATLI
    61  DEPTEVDDPW NLPTLQDSGI KWSERDTKGK ILCFFQGIGR LILLLGFLYF FVCSLDILSS
   121  AFQLVGGKMA GQFFSNSSIM SNPLLGLVIG VLVTVLVQSS STSTSIVVSM VSSSLLTVRA
   181  AIPIIMGANI GTSITNTIVA LMQVGDRSEF RRAFAGATVH DFFNWLSVLV LLPVEVATHY
   241  LEIITQLIVE SFHFKNGEDA PDLLKVITKP FTKLIVQLDK KVISQIAMND EKAKNKSLVK
   301  IWCKTFTNKT QINVTVPSTA NCTSPSLCWT DGIQNWTMKN VTYKENIAKC QHIFVNFHLP
   361  DLAVGTILLI LSLLVLCGCL IMIVKILGSV LKGQVATVIK KTINTDFPFP FAWLTGYLAI
   421  LVGAGMTFIV QSSSVFTSAL TPLIGIGVIT IERAYPLTLG SNIGTTTTAI LAALASPGNA
   481  LRSSLQIALC HFFFNISGIL LWYPIPFTRL PIRMAKGLGN ISAKYRWFAV FYLIIFFFLI
   541  PLTVFGLSLA GWRVLVGVGV PVVFIIILVL CLRLLQSRCP RVLPKKLQNW NFLPLWMRSL
   601  KPWDAVVSKF TGCFQMRCCC CCRVCCRACC LLCDCPKCCR CSKCCEDLEE AQEGQDVPVK
   661  APETFDNITI SREAQGEVPA SDSKTECTAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC34A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
8
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
710 nTPM

Expression across tissuesHPA

Tissue

  • lung: 710 nTPM
  • salivary gland: 84 nTPM
  • fallopian tube: 66 nTPM
  • cervix: 63 nTPM
  • endometrium: 32 nTPM
  • thyroid gland: 32 nTPM

Single-cell type

  • alveolar cells type 2: 1,909 nCPM
  • transitional alveolar cells: 1,121 nCPM
  • alveolar cells type 1: 867 nCPM
  • endometrial secretory cells: 444 nCPM
  • endometrial glandular cells: 420 nCPM
  • breast lactating cells: 291 nCPM

Immune cell

  • basophil: 0.1 nTPM
  • neutrophil: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • choroid plexus: 16 nTPM
  • cerebellum: 5.4 nTPM
  • thalamus: 1.7 nTPM
  • cerebral cortex: 1.4 nTPM
  • basal ganglia: 1.1 nTPM
  • hippocampal formation: 1.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC34A2.

Disease | AllUniProt

Conditions SLC34A2 is implicated in, by any mechanism.

  • Pulmonary alveolar microlithiasis (PULAM) MIM:265100

Disease | GeneticClinVar

19 pathogenic / likely-pathogenic of 230 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.09
gnomAD pLI
0
gnomAD missense Z
0.14
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC34A2 as an antibody target. Whether an autoantibody or antibody against SLC34A2 could matter depends on whether native SLC34A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC34A2 is annotated at the cell surface, where native SLC34A2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC34A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC34A2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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