Seroatlas · Human Serome Atlas

SLC32A1

Vesicular inhibitory amino acid transporter

Also known as: bA122O1.1, VGAT, VIAAT, VIAAT_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H598
Gene
SLC32A1
Ensembl
ENSG00000101438
Chromosome
20
Canonical length
525 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location
Cytosol

OverviewNCBI Gene

The protein encoded by this gene is an integral membrane protein involved in gamma-aminobutyric acid (GABA) and glycine uptake into synaptic vesicles. The encoded protein is a member of amino acid/polyamine transporter family II. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

525 residues, UniProt reviewed canonical sequence.

>Q9H598|SLC32A1
     1  MATLLRSKLS NVATSVSNKS QAKMSGMFAR MGFQAATDEE AVGFAHCDDL DFEHRQGLQM
    61  DILKAEGEPC GDEGAEAPVE GDIHYQRGSG APLPPSGSKD QVGGGGEFGG HDKPKITAWE
   121  AGWNVTNAIQ GMFVLGLPYA ILHGGYLGLF LIIFAAVVCC YTGKILIACL YEENEDGEVV
   181  RVRDSYVAIA NACCAPRFPT LGGRVVNVAQ IIELVMTCIL YVVVSGNLMY NSFPGLPVSQ
   241  KSWSIIATAV LLPCAFLKNL KAVSKFSLLC TLAHFVINIL VIAYCLSRAR DWAWEKVKFY
   301  IDVKKFPISI GIIVFSYTSQ IFLPSLEGNM QQPSEFHCMM NWTHIAACVL KGLFALVAYL
   361  TWADETKEVI TDNLPGSIRA VVNIFLVAKA LLSYPLPFFA AVEVLEKSLF QEGSRAFFPA
   421  CYSGDGRLKS WGLTLRCALV VFTLLMAIYV PHFALLMGLT GSLTGAGLCF LLPSLFHLRL
   481  LWRKLLWHQV FFDVAIFVIG GICSVSGFVH SLEGLIEAYR TNAED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC32A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
9
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
44 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 44 nTPM
  • hypothalamus: 16 nTPM
  • cerebral cortex: 13 nTPM
  • cerebellum: 7.6 nTPM
  • pituitary gland: 7.2 nTPM
  • amygdala: 6.1 nTPM

Single-cell type

  • retinal amacrine cells: 55 nCPM
  • brain inhibitory neurons: 33 nCPM
  • retinal horizontal cells: 32 nCPM
  • other brain neurons: 28 nCPM
  • pdcs: 28 nCPM
  • corticotrophs: 4.2 nCPM

Immune cell

  • plasmacytoid DC: 0.2 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • hypothalamus: 99 nTPM
  • basal ganglia: 98 nTPM
  • medulla oblongata: 44 nTPM
  • amygdala: 37 nTPM
  • cerebral cortex: 35 nTPM
  • pons: 31 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC32A1.

Disease | AllUniProt

Conditions SLC32A1 is implicated in, by any mechanism.

  • Generalized epilepsy with febrile seizures plus 12 (GEFSP12) MIM:620755
  • Developmental and epileptic encephalopathy 114 (DEE114) MIM:620774

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 95 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.32
gnomAD pLI
0.97
gnomAD missense Z
2.3
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC32A1 as an antibody target. Whether an autoantibody or antibody against SLC32A1 could matter depends on whether native SLC32A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC32A1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC32A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC32A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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