Seroatlas · Human Serome Atlas

SLC2A4RG

SLC2A4 regulator

Also known as: GEF, HDBP1, S2A4R_HUMAN, Si-1-2, Si-1-2-19

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NR83
Gene: SLC2A4RG
Ensembl: ENSG00000125520
Chromosome: 20
Canonical length: 387 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles

OverviewNCBI Gene

The protein encoded by this gene is a nuclear transcription factor involved in the activation of the solute carrier family 2 member 4 gene. The encoded protein interacts with another transcription factor, myocyte enhancer factor 2, to activate transcription of this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

387 residues, UniProt reviewed canonical sequence.

>Q9NR83|SLC2A4RG
     1  MERPPPRAAG RDPSALRAEA PWLRAEGPGP RAAPVTVPTP PQGSSVGGGF AGLEFARPQE
    61  SEPRASDLGA PRTWTGAAAG PRTPSAHIPV PAQRATPGKA RLDEVMAAAA LTSLSTSPLL
   121  LGAPVAAFSP EPGLEPWKEA LVRPPGSYSS SSNSGDWGWD LASDQSSPST PSPPLPPEAA
   181  HFLFGEPTLR KRKSPAQVMF QCLWKSCGKV LSTASAMQRH IRLVHLGRQA EPEQSDGEED
   241  FYYTELDVGV DTLTDGLSSL TPVSPTASMP PAFPRLELPE LLEPPALPSP LRPPAPPLPP
   301  PPVLSTVANP QSCHSDRVYQ GCLTPARLEP QPTEVGACPP ALSSRIGVTL RKPRGDAKKC
   361  RKVYGMERRD LWCTACRWKK ACQRFLD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC2A4RG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 86 nTPM

Expression across tissuesHPA

Tissue

liver: 86 nTPM
kidney: 45 nTPM
skeletal muscle: 44 nTPM
heart muscle: 36 nTPM
adipose tissue: 30 nTPM
blood vessel: 28 nTPM

Single-cell type

hepatocytes: 142 nCPM
breast myoepithelial cells: 104 nCPM
breast lactating cells: 100 nCPM
smooth muscle cells: 85 nCPM
erythrocyte progenitors: 77 nCPM
sertoli cells: 68 nCPM

Immune cell

T-reg: 1.1 nTPM
gdT-cell: 0.9 nTPM
memory CD4 T-cell: 0.9 nTPM
naive CD4 T-cell: 0.7 nTPM
naive CD8 T-cell: 0.7 nTPM
memory CD8 T-cell: 0.5 nTPM

Brain region

spinal cord: 11 nTPM
amygdala: 11 nTPM
basal ganglia: 11 nTPM
white matter: 11 nTPM
medulla oblongata: 10 nTPM
hypothalamus: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.68
gnomAD pLI: 0.22
gnomAD missense Z: 0.19
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC2A4RG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

MEF2A

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC2A4RG as an antibody target. Whether an autoantibody or antibody against SLC2A4RG could matter depends on whether native SLC2A4RG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC2A4RG is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC2A4RG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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