Seroatlas · Human Serome Atlas

SLC28A3

Solute carrier family 28 member 3

Also known as: CNT3, S28A3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9HAS3
Gene
SLC28A3
Ensembl
ENSG00000197506
Chromosome
9
Canonical length
691 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters
Quaternary structure
Homotrimer

OverviewNCBI Gene

Nucleoside transporters, such as SLC28A3, regulate multiple cellular processes, including neurotransmission, vascular tone, adenosine concentration in the vicinity of cell surface receptors, and transport and metabolism of nucleoside drugs. SLC28A3 shows broad specificity for pyrimidine and purine nucleosides (Ritzel et al., 2001 [PubMed 11032837]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

691 residues, UniProt reviewed canonical sequence.

>Q9HAS3|SLC28A3
     1  MELRSTAAPR AEGYSNVGFQ NEENFLENEN TSGNNSIRSR AVQSREHTNT KQDEEQVTVE
    61  QDSPRNREHM EDDDEEMQQK GCLERRYDTV CGFCRKHKTT LRHIIWGILL AGYLVMVISA
   121  CVLNFHRALP LFVITVAAIF FVVWDHLMAK YEHRIDEMLS PGRRLLNSHW FWLKWVIWSS
   181  LVLAVIFWLA FDTAKLGQQQ LVSFGGLIMY IVLLFLFSKY PTRVYWRPVL WGIGLQFLLG
   241  LLILRTDPGF IAFDWLGRQV QTFLEYTDAG ASFVFGEKYK DHFFAFKVLP IVVFFSTVMS
   301  MLYYLGLMQW IIRKVGWIML VTTGSSPIES VVASGNIFVG QTESPLLVRP YLPYITKSEL
   361  HAIMTAGFST IAGSVLGAYI SFGVPSSHLL TASVMSAPAS LAAAKLFWPE TEKPKITLKN
   421  AMKMESGDSG NLLEAATQGA SSSISLVANI AVNLIAFLAL LSFMNSALSW FGNMFDYPQL
   481  SFELICSYIF MPFSFMMGVE WQDSFMVARL IGYKTFFNEF VAYEHLSKWI HLRKEGGPKF
   541  VNGVQQYISI RSEIIATYAL CGFANIGSLG IVIGGLTSMA PSRKRDIASG AVRALIAGTV
   601  ACFMTACIAG ILSSTPVDIN CHHVLENAFN STFPGNTTKV IACCQSLLSS TVAKGPGEVI
   661  PGGNHSLYSL KGCCTLLNPS TFNCNGISNT F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC28A3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
11
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
32 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 32 nTPM
  • salivary gland: 12 nTPM
  • skin: 9.4 nTPM
  • bone marrow: 8.9 nTPM
  • breast: 8.3 nTPM
  • pancreas: 7.7 nTPM

Single-cell type

  • choroid plexus epithelial cells: 139 nCPM
  • pancreatic duct cells: 135 nCPM
  • mesothelial cells: 118 nCPM
  • fallopian secretory cells: 67 nCPM
  • esophageal apical cells: 61 nCPM
  • salivary acinar cells: 60 nCPM

Immune cell

  • intermediate monocyte: 0.5 nTPM
  • NK-cell: 0.1 nTPM
  • non-classical monocyte: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • choroid plexus: 47 nTPM
  • midbrain: 2.1 nTPM
  • medulla oblongata: 2 nTPM
  • hippocampal formation: 1.8 nTPM
  • spinal cord: 0.8 nTPM
  • thalamus: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.24
gnomAD pLI
0
gnomAD missense Z
1.07
DepMap mean gene effect
-0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC28A3 as an antibody target. Whether an autoantibody or antibody against SLC28A3 could matter depends on whether native SLC28A3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC28A3 is annotated at the cell surface, where native SLC28A3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC28A3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC28A3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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