Seroatlas · Human Serome Atlas

SLC25A53

Solute carrier family 25 member 53

Also known as: MCART6, S2553_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5H9E4
Gene: SLC25A53
Ensembl: ENSG00000269743
Chromosome: X
Canonical length: 307 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable NAD transmembrane transporter activity. Predicted to be involved in NAD transmembrane transport. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

307 residues, UniProt reviewed canonical sequence.

>Q5H9E4|SLC25A53
     1  MGEQNHSPGK ELQHRTRAEA PGKKSWHSQA YALGAVSNFM STFLTFPIYK VVFRQQIHAM
    61  AVSEAVRQLW HEGPQYFYRG IYPPLLSKTL QGTLLFGTYD SLLCFLSPVG PHTLGHRWAA
   121  GLMSGVVEAV ALSPFERVQN VLQDGRKQAR FPSTFSILKE FNSYGLWGRL SLGYYRGFWP
   181  VLARNSLGSA LYFSFKDPIQ DGLAEQGLPH WVPALVSGSV NGTITCLVLY PLIVLVANMQ
   241  SHIGWQNMPS LWASAQDVWN TRGRKLLLIY RGGSLVILRS SVTWGLTTAI HDFLQRKSHS
   301  RKELKTD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC25A53 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 1.7 nTPM

Expression across tissuesHPA

Tissue

lymph node: 1.7 nTPM
tonsil: 1.5 nTPM
cerebral cortex: 1.4 nTPM
spleen: 1.2 nTPM
appendix: 1 nTPM
small intestine: 0.9 nTPM

Single-cell type

choroid plexus epithelial cells: 57 nCPM
lactotrophs: 54 nCPM
corticotrophs: 54 nCPM
rod photoreceptor cells: 53 nCPM
distal convoluted tubule cells: 53 nCPM
renal connecting tubule cells: 52 nCPM

Immune cell

neutrophil: 0.7 nTPM
MAIT T-cell: 0.6 nTPM
memory B-cell: 0.5 nTPM
memory CD8 T-cell: 0.5 nTPM
T-reg: 0.5 nTPM
naive B-cell: 0.4 nTPM

Brain region

cerebellum: 4.3 nTPM
white matter: 4.3 nTPM
hippocampal formation: 4 nTPM
midbrain: 4 nTPM
spinal cord: 4 nTPM
thalamus: 3.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.04
gnomAD pLI: 0.06
gnomAD missense Z: 0.67
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

NAD transmembrane transporter activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC25A53 as an antibody target. Whether an autoantibody or antibody against SLC25A53 could matter depends on whether native SLC25A53 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC25A53 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC25A53 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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