Seroatlas · Human Serome Atlas

SLC25A52

Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A52

Also known as: MCART2, S2552_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q3SY17
Gene: SLC25A52
Ensembl: ENSG00000141437
Chromosome: 18
Canonical length: 297 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Mitochondria

OverviewNCBI Gene

This gene is similar to the mitochondrial carrier triple repeat 1 gene on chromosome 9. The gene is intronless and may be an evolving pseudogene; however, it is transcribed and it contains a full-length coding region so it is currently classified as a protein-coding locus. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

297 residues, UniProt reviewed canonical sequence.

>Q3SY17|SLC25A52
     1  MIDSEAHEKR PPILTSSKQD ISPHITNVGE MKHYLCGCCA AFNNVAITYP IQKVLFRQQL
    61  YGIKTRDAVL QLRRDGFRNL YRGILPPLMQ KTTTLALMFG LYEDLSCLLR KHVRAPEFAT
   121  HGVAAVLAGT AEAIFTPLER VQTLLQNHKH HDKFTNTYQA FKALKCHGIG EYYRGLVPIL
   181  FRNGLSNVLF FGLRGPIKEH LPTATTHSAH LVNDFIGGGL LGAMLGFLCF PINVVKTRLQ
   241  SQIGGEFQSF PKVFQKIWLE RDRKLINLFR GAHLNYHRSL ISWGIINATY EFLLKFI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC25A52 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 9.7 nTPM

Expression across tissuesHPA

Tissue

testis: 9.7 nTPM
liver: 0.6 nTPM
skeletal muscle: 0.5 nTPM
adipose tissue: 0.2 nTPM
pituitary gland: 0.2 nTPM
adrenal gland: 0.1 nTPM

Single-cell type

late spermatids: 164 nCPM
late primary spermatocytes: 58 nCPM
early spermatids: 49 nCPM
early primary spermatocytes: 2.3 nCPM
sertoli cells: 1.1 nCPM
undifferentiated spermatogonia: 1.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 1.3 nTPM
pons: 1.2 nTPM
cerebral cortex: 1.1 nTPM
choroid plexus: 1 nTPM
hippocampal formation: 1 nTPM
hypothalamus: 1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.76
gnomAD pLI: 0
gnomAD missense Z: 0.09
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

mitochondrial NAD transmembrane transport

Molecular functions

NAD transmembrane transporter activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC25A52 as an antibody target. Whether an autoantibody or antibody against SLC25A52 could matter depends on whether native SLC25A52 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC25A52 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC25A52 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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