SLC25A51
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51
Also known as: CG7943, MCART1, MGC14836, S2551_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9H1U9
- Gene
- SLC25A51
- Ensembl
- ENSG00000122696
- Chromosome
- 9
- Canonical length
- 297 aa
- Protein class
- Predicted membrane proteins, Transporters
- Subcellular location
- Mitochondria
OverviewNCBI Gene
Enables NAD transmembrane transporter activity. Involved in mitochondrial NAD transmembrane transport. Located in mitochondrion. Is active in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
297 residues, UniProt reviewed canonical sequence.
>Q9H1U9|SLC25A51
1 MMDSEAHEKR PPILTSSKQD ISPHITNVGE MKHYLCGCCA AFNNVAITFP IQKVLFRQQL
61 YGIKTRDAIL QLRRDGFRNL YRGILPPLMQ KTTTLALMFG LYEDLSCLLH KHVSAPEFAT
121 SGVAAVLAGT TEAIFTPLER VQTLLQDHKH HDKFTNTYQA FKALKCHGIG EYYRGLVPIL
181 FRNGLSNVLF FGLRGPIKEH LPTATTHSAH LVNDFICGGL LGAMLGFLFF PINVVKTRIQ
241 SQIGGEFQSF PKVFQKIWLE RDRKLINLFR GAHLNYHRSL ISWGIINATY EFLLKVILocalizationUniProt · AlphaFold · HPA
Whether an antibody against SLC25A51 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 6
- Mean surface accessibility (rSASA)
- 0.33
- Highest tissue expression
- 11 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 11 nTPM
- adipose tissue: 8.5 nTPM
- testis: 8 nTPM
- parathyroid gland: 7.9 nTPM
- duodenum: 7.1 nTPM
- tongue: 6.9 nTPM
Single-cell type
- brain inhibitory neurons: 29 nCPM
- oligodendrocytes: 28 nCPM
- choroid plexus epithelial cells: 28 nCPM
- brain excitatory neurons: 28 nCPM
- other brain neurons: 27 nCPM
- bergmann glia: 25 nCPM
Immune cell
- basophil: 17 nTPM
- intermediate monocyte: 3.2 nTPM
- eosinophil: 2.8 nTPM
- MAIT T-cell: 2.8 nTPM
- memory B-cell: 2.7 nTPM
- T-reg: 2.7 nTPM
Brain region
- cerebral cortex: 20 nTPM
- hypothalamus: 20 nTPM
- pons: 19 nTPM
- white matter: 19 nTPM
- midbrain: 18 nTPM
- cerebellum: 18 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.2
- gnomAD pLI
- 0
- gnomAD missense Z
- 2
- DepMap mean gene effect
- -0.23
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- mitochondrial NAD transmembrane transport
- nicotinate metabolic process
- aerobic electron transport chain
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SLC25A51 as an antibody target. Whether an autoantibody or antibody against SLC25A51 could matter depends on whether native SLC25A51 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SLC25A51 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SLC25A51 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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