Seroatlas · Human Serome Atlas

SLC25A48

Solute carrier family 25 member 48

Also known as: FLJ44862, S2548_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZT89
Gene: SLC25A48
Ensembl: ENSG00000145832
Chromosome: 5
Canonical length: 311 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Intermediate filaments,Actin filaments

OverviewNCBI Gene

Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

311 residues, UniProt reviewed canonical sequence.

>Q6ZT89|SLC25A48
     1  MGSFQLEDFA AGWIGGAASV IVGHPLDTVK TRLQAGVGYG NTLSCIRVVY RRESMFGFFK
    61  GMSFPLASIA VYNSVVFGVF SNTQRFLSQH RCGEPEASPP RTLSDLLLAS MVAGVVSVGL
   121  GGPVDLIKIR LQMQTQPFRD ANLGLKSRAV APAEQPAYQG PVHCITTIVR NEGLAGLYRG
   181  ASAMLLRDVP GYCLYFIPYV FLSEWITPEA CTGPSPCAVW LAGGMAGAIS WGTATPMDVV
   241  KSRLQADGVY LNKYKGVLDC ISQSYQKEGL KVFFRGITVN AVRGFPMSAA MFLGYELSLQ
   301  AIRGDHAVTS P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC25A48 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

amygdala: 15 nTPM
basal ganglia: 14 nTPM
hippocampal formation: 13 nTPM
midbrain: 13 nTPM
cerebral cortex: 13 nTPM
hypothalamus: 11 nTPM

Single-cell type

proximal tubule cells: 177 nCPM
astrocytes: 158 nCPM
pituicytes/fscs: 128 nCPM
fibro-adipogenic progenitors: 55 nCPM
loop of henle epithelial cells: 53 nCPM
endometrial glandular cells: 40 nCPM

Immune cell

basophil: 0.2 nTPM
neutrophil: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

white matter: 50 nTPM
thalamus: 33 nTPM
midbrain: 32 nTPM
hypothalamus: 32 nTPM
pons: 30 nTPM
spinal cord: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.68
gnomAD pLI: 0
gnomAD missense Z: 0.79
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

choline transport

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC25A48 as an antibody target. Whether an autoantibody or antibody against SLC25A48 could matter depends on whether native SLC25A48 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC25A48 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC25A48 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...