Seroatlas · Human Serome Atlas

SLC25A47

Solute carrier family 25 member 47

Also known as: C14orf68, HDCMP, S2547_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6Q0C1
Gene: SLC25A47
Ensembl: ENSG00000140107
Chromosome: 14
Canonical length: 308 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a member of a large family of mitochondrial transporters. The nuclear-encoded carrier protein is embedded in the inner mitochondrial membrane. This member of the family is thought to be an uncoupling protein that uncouples mitochondrial respiration from ATP synthesis by dissipating the transmembrane proton gradient. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]

Canonical amino-acid sequenceUniProt

308 residues, UniProt reviewed canonical sequence.

>Q6Q0C1|SLC25A47
     1  MDFVAGAIGG VCGVAVGYPL DTVKVRIQTE PKYTGIWHCV RDTYHRERVW GFYRGLSLPV
    61  CTVSLVSSVS FGTYRHCLAH ICRLRYGNPD AKPTKADITL SGCASGLVRV FLTSPTEVAK
   121  VRLQTQTQAQ KQQRRLSASG PLAVPPMCPV PPACPEPKYR GPLHCLATVA REEGLCGLYK
   181  GSSALVLRDG HSFATYFLSY AVLCEWLSPA GHSRPDVPGV LVAGGCAGVL AWAVATPMDV
   241  IKSRLQADGQ GQRRYRGLLH CMVTSVREEG PRVLFKGLVL NCCRAFPVNM VVFVAYEAVL
   301  RLARGLLT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC25A47 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 509 nTPM

Expression across tissuesHPA

Tissue

liver: 509 nTPM
kidney: 1.4 nTPM
duodenum: 0.5 nTPM
testis: 0.5 nTPM
small intestine: 0.4 nTPM
spleen: 0.2 nTPM

Single-cell type

hepatocytes: 350 nCPM
epididymal efferent duct absorptive cells: 8.3 nCPM
hepatic stellate cells: 6.5 nCPM
endometrial luminal cells: 4.1 nCPM
enterocytes: 3.4 nCPM
epididymal efferent duct ciliated cells: 3.4 nCPM

Immune cell

neutrophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 0.3 nTPM
cerebral cortex: 0.3 nTPM
amygdala: 0.2 nTPM
basal ganglia: 0.2 nTPM
hippocampal formation: 0.2 nTPM
medulla oblongata: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.67
gnomAD pLI: 0
gnomAD missense Z: 0.38
DepMap mean gene effect: 0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC25A47 as an antibody target. Whether an autoantibody or antibody against SLC25A47 could matter depends on whether native SLC25A47 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC25A47 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC25A47 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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