Seroatlas · Human Serome Atlas

SLC25A45

Solute carrier family 25 member 45

Also known as: S2545_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N413
Gene: SLC25A45
Ensembl: ENSG00000162241
Chromosome: 11
Canonical length: 288 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

288 residues, UniProt reviewed canonical sequence.

>Q8N413|SLC25A45
     1  MPVEEFVAGW ISGALGLVLG HPFDTVKVRL QTQTTYRGIV DCMVKIYRHE SLLGFFKGMS
    61  FPIASIAVVN SVLFGVYSNT LLVLTATSHQ ERRAQPPSYM HIFLAGCTGG FLQAYCLAPF
   121  DLIKVRLQNQ TEPRAQPGSP PPRYQGPVHC AASIFREEGP RGLFRGAWAL TLRDTPTVGI
   181  YFITYEGLCR QYTPEGQNPS SATVLVAGGF AGIASWVAAT PLDMIKSRMQ MDGLRRRVYQ
   241  GMLDCMVSSI RQEGLGVFFR GVTINSARAF PVNAVTFLSY EYLLRWWG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC25A45 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

pancreas: 32 nTPM
spleen: 13 nTPM
thyroid gland: 12 nTPM
liver: 12 nTPM
lymph node: 10 nTPM
thymus: 8.1 nTPM

Single-cell type

granulosa cells: 113 nCPM
enterocytes: 89 nCPM
pancreatic acinar cells: 68 nCPM
sertoli cells: 58 nCPM
myonuclei: 41 nCPM
plasma cells: 31 nCPM

Immune cell

plasmacytoid DC: 23 nTPM
NK-cell: 18 nTPM
non-classical monocyte: 13 nTPM
naive CD4 T-cell: 13 nTPM
naive B-cell: 12 nTPM
intermediate monocyte: 11 nTPM

Brain region

white matter: 3.7 nTPM
medulla oblongata: 3 nTPM
cerebral cortex: 2.8 nTPM
pons: 2.5 nTPM
spinal cord: 2.3 nTPM
basal ganglia: 2.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.36
gnomAD pLI: 0
gnomAD missense Z: 0.13
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

transmembrane transporter activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC25A45 as an antibody target. Whether an autoantibody or antibody against SLC25A45 could matter depends on whether native SLC25A45 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC25A45 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC25A45 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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