SLC25A44
Solute carrier family 25 member 44
Also known as: FLJ90431, KIAA0446, S2544_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96H78
- Gene
- SLC25A44
- Ensembl
- ENSG00000160785
- Chromosome
- 1
- Canonical length
- 314 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins, Transporters
- Subcellular location
- Nucleoplasm,Mitochondria
OverviewNCBI Gene
SLC25A44 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]
Canonical amino-acid sequenceUniProt
314 residues, UniProt reviewed canonical sequence.
>Q96H78|SLC25A44
1 MEDKRNIQII EWEHLDKKKF YVFGVAMTMM IRVSVYPFTL IRTRLQVQKG KSLYHGTFDA
61 FIKILRADGI TGLYRGFLVN TFTLISGQCY VTTYELTRKF VADYSQSNTV KSLVAGGSAS
121 LVAQSITVPI DVVSQHLMMQ RKGEKMGRFQ VRGNPEGQGV VAFGQTKDII RQILQADGLR
181 GFYRGYVASL LTYIPNSAVW WPFYHFYAEQ LSYLCPKECP HIVFQAVSGP LAAATASILT
241 NPMDVIRTRV QVEGKNSIIL TFRQLMAEEG PWGLMKGLSA RIISATPSTI VIVVGYESLK
301 KLSLRPELVD SRHWLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SLC25A44 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 6
- Mean surface accessibility (rSASA)
- 0.31
- Highest tissue expression
- 35 nTPM
Expression across tissuesHPA
Tissue
- liver: 35 nTPM
- kidney: 26 nTPM
- cerebral cortex: 26 nTPM
- cerebellum: 21 nTPM
- tongue: 20 nTPM
- hypothalamus: 18 nTPM
Single-cell type
- salivary basal cells: 171 nCPM
- early spermatids: 164 nCPM
- salivary myoepithelial cells: 152 nCPM
- late spermatids: 147 nCPM
- neutrophils: 117 nCPM
- endometrial luminal cells: 88 nCPM
Immune cell
- neutrophil: 71 nTPM
- eosinophil: 19 nTPM
- intermediate monocyte: 19 nTPM
- classical monocyte: 18 nTPM
- non-classical monocyte: 16 nTPM
- basophil: 15 nTPM
Brain region
- cerebral cortex: 50 nTPM
- basal ganglia: 36 nTPM
- thalamus: 35 nTPM
- white matter: 35 nTPM
- pons: 35 nTPM
- midbrain: 34 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.95
- gnomAD pLI
- 0
- gnomAD missense Z
- 1.95
- DepMap mean gene effect
- -0.13
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 15% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- amino acid transport
- branched-chain amino acid catabolic process
- regulation of cold-induced thermogenesis
- branched-chain amino acid transport
Molecular functions
- branched-chain amino acid transmembrane transporter activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SLC25A44 as an antibody target. Whether an autoantibody or antibody against SLC25A44 could matter depends on whether native SLC25A44 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SLC25A44 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SLC25A44 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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