Seroatlas · Human Serome Atlas

SLC25A43

Solute carrier family 25 member 43

Also known as: S2543_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WUT9
Gene: SLC25A43
Ensembl: ENSG00000077713
Chromosome: X
Canonical length: 341 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Cytosol

OverviewNCBI Gene

This gene encodes a member of the mitochondrial carrier family of proteins.[provided by RefSeq, Dec 2009]

Canonical amino-acid sequenceUniProt

341 residues, UniProt reviewed canonical sequence.

>Q8WUT9|SLC25A43
     1  MATWRRDGRL TGGQRLLCAG LAGTLSLSLT APLELATVLA QVGVVRGHAR GPWATGHRVW
    61  RAEGLRALWK GNAVACLRLF PCSAVQLAAY RKFVVLFTDD LGHISQWSSI MAGSLAGMVS
   121  TIVTYPTDLI KTRLIMQNIL EPSYRGLLHA FSTIYQQEGF LALYRGVSLT VVGALPFSAG
   181  SLLVYMNLEK IWNGPRDQFS LPQNFANVCL AAAVTQTLSF PFETVKRKMQ AQSPYLPHSG
   241  GVDVHFSGAV DCFRQIVKAQ GVLGLWNGLT ANLLKIVPYF GIMFSTFEFC KRICLYQNGY
   301  ILSPLSYKLT PGVDQSLQPQ ELRELKKFFK TRKPKPKKPT L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC25A43 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

esophagus: 24 nTPM
skin: 15 nTPM
rectum: 15 nTPM
duodenum: 13 nTPM
vagina: 13 nTPM
colon: 13 nTPM

Single-cell type

esophageal apical cells: 240 nCPM
esophageal suprabasal cells: 178 nCPM
fibro-adipogenic progenitors: 144 nCPM
alveolar cells type 1: 114 nCPM
adipocytes: 83 nCPM
pituitary stem cells: 82 nCPM

Immune cell

non-classical monocyte: 11 nTPM
NK-cell: 6.4 nTPM
myeloid DC: 6 nTPM
intermediate monocyte: 4.9 nTPM
memory B-cell: 4.4 nTPM
naive B-cell: 3.7 nTPM

Brain region

choroid plexus: 8.8 nTPM
medulla oblongata: 6.6 nTPM
white matter: 5.3 nTPM
thalamus: 5.2 nTPM
hypothalamus: 5.1 nTPM
pons: 5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.89
gnomAD pLI: 0.09
gnomAD missense Z: 1.25
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

transmembrane transport

Cellular components

mitochondrial inner membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC25A43 as an antibody target. Whether an autoantibody or antibody against SLC25A43 could matter depends on whether native SLC25A43 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC25A43 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC25A43 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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