Seroatlas · Human Serome Atlas

SLC25A41

Mitochondrial carrier protein SCaMC-3L

Also known as: APC4, FLJ40442, MGC34725, S2541_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N5S1
Gene: SLC25A41
Ensembl: ENSG00000181240
Chromosome: 19
Canonical length: 370 aa
Protein class: Predicted intracellular proteins, Transporters

OverviewNCBI Gene

SLC25A41 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

370 residues, UniProt reviewed canonical sequence.

>Q8N5S1|SLC25A41
     1  MGAQPGEPQN TCSRIQTLFR RVKTLLIKAP PPPQPPPPPP SWNPGCTHVY GYAFGHMHDN
    61  NLEHLPSQQV LDTGEQLMVP VEVLEVDNKE ALWKFLLSGA MAGAVSRTGT APLDRAKVYM
   121  QVYSSKTNFT NLLGGLQSMV QEGGFRSLWR GNGINVLKIA PEYAIKFSVF EQCKNYFCGI
   181  QGSPPFQERL LAGSLAVAIS QTLINPMEVL KTRLTLRRTG QYKGLLDCAR QILQREGTRA
   241  LYRGYLPNML GIIPYACTDL AVYEMLQCFW VKSGRDMGDP SGLVSLSSVT LSTTCGQMAS
   301  YPLTLVRTRM QAQDTVEGSN PTMRGVLQRI LAQQGWLGLY RGMTPTLLKV LPAGGISYVV
   361  YEAMKKTLGI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC25A41 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 8.1 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 8.1 nTPM
basal ganglia: 5.8 nTPM
cerebral cortex: 3.1 nTPM
hippocampal formation: 3 nTPM
amygdala: 2.6 nTPM
testis: 2.1 nTPM

Single-cell type

early spermatids: 280 nCPM
late spermatids: 32 nCPM
late primary spermatocytes: 16 nCPM
brain inhibitory neurons: 9.3 nCPM
brain excitatory neurons: 8.4 nCPM
retinal amacrine cells: 7.9 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 2.2 nTPM
pons: 1.4 nTPM
cerebral cortex: 1.3 nTPM
hippocampal formation: 1 nTPM
hypothalamus: 1 nTPM
amygdala: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.52
gnomAD pLI: 0
gnomAD missense Z: -0.18
DepMap mean gene effect: -0.28
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC25A41 as an antibody target. Whether an autoantibody or antibody against SLC25A41 could matter depends on whether native SLC25A41 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC25A41 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC25A41 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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