Seroatlas · Human Serome Atlas

SLC25A40

Mitochondrial glutathione transporter SLC25A40

Also known as: MCFP, S2540_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TBP6
Gene: SLC25A40
Ensembl: ENSG00000075303
Chromosome: 7
Canonical length: 338 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

SLC25A40 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

338 residues, UniProt reviewed canonical sequence.

>Q8TBP6|SLC25A40
     1  MDPETRGQEI IKVTPLQQML ASCTGAILTS VIVTPLDVVK IRLQAQNNPL PKGKCFVYSN
    61  GLMDHLCVCE EGGNKLWYKK PGNFQGTLDA FFKIIRNEGI KSLWSGLPPT LVMAVPATVI
   121  YFTCYDQLSA LLRSKLGENE TCIPIVAGIV ARFGAVTVIS PLELIRTKMQ SKKFSYVELH
   181  RFVSKKVSED GWISLWRGWA PTVLRDVPFS AMYWYNYEIL KKWLCEKSGL YEPTFMINFT
   241  SGALSGSFAA VATLPFDVVK TQKQTQLWTY ESHKISMPLH MSTWIIMKNI VAKNGFSGLF
   301  SGLIPRLIKI APACAIMIST YEFGKAFFQK QNVRRQQY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC25A40 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 9.9 nTPM

Expression across tissuesHPA

Tissue

lymph node: 9.9 nTPM
tonsil: 9.3 nTPM
heart muscle: 9.1 nTPM
rectum: 9 nTPM
thymus: 9 nTPM
parathyroid gland: 8.9 nTPM

Single-cell type

neutrophil progenitors: 233 nCPM
neutrophils: 131 nCPM
monocyte progenitors: 68 nCPM
myonuclei: 50 nCPM
bergmann glia: 50 nCPM
innate lymphoid cells: 47 nCPM

Immune cell

basophil: 9.1 nTPM
eosinophil: 5 nTPM
NK-cell: 4 nTPM
non-classical monocyte: 4 nTPM
myeloid DC: 3.9 nTPM
intermediate monocyte: 3.7 nTPM

Brain region

cerebellum: 21 nTPM
cerebral cortex: 21 nTPM
thalamus: 21 nTPM
midbrain: 19 nTPM
pons: 18 nTPM
hypothalamus: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.03
gnomAD pLI: 0
gnomAD missense Z: 0.91
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

glutathione transmembrane transporter activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC25A40 as an antibody target. Whether an autoantibody or antibody against SLC25A40 could matter depends on whether native SLC25A40 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC25A40 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC25A40 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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