Seroatlas · Human Serome Atlas

SLC25A39

Mitochondrial glutathione transporter SLC25A39

Also known as: CGI-69, FLJ22407, S2539_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BZJ4
Gene: SLC25A39
Ensembl: ENSG00000013306
Chromosome: 17
Canonical length: 359 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a member of the SLC25 transporter or mitochondrial carrier family of proteins. Members of this family are encoded by the nuclear genome while their protein products are usually embedded in the inner mitochondrial membrane and exhibit wide-ranging substrate specificity. Although the encoded protein is currently considered an orphan transporter, this protein is related to other carriers known to transport amino acids. This protein may play a role in iron homeostasis. [provided by RefSeq, Mar 2016]

Canonical amino-acid sequenceUniProt

359 residues, UniProt reviewed canonical sequence.

>Q9BZJ4|SLC25A39
     1  MADQDPAGIS PLQQMVASGT GAVVTSLFMT PLDVVKVRLQ SQRPSMASEL MPSSRLWSLS
    61  YTKLPSSLQS TGKCLLYCNG VLEPLYLCPN GARCATWFQD PTRFTGTMDA FVKIVRHEGT
   121  RTLWSGLPAT LVMTVPATAI YFTAYDQLKA FLCGRALTSD LYAPMVAGAL ARLGTVTVIS
   181  PLELMRTKLQ AQHVSYRELG ACVRTAVAQG GWRSLWLGWG PTALRDVPFS ALYWFNYELV
   241  KSWLNGFRPK DQTSVGMSFV AGGISGTVAA VLTLPFDVVK TQRQVALGAM EAVRVNPLHV
   301  DSTWLLLRRI RAESGTKGLF AGFLPRIIKA APSCAIMIST YEFGKSFFQR LNQDRLLGG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC25A39 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 288 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 288 nTPM
kidney: 172 nTPM
esophagus: 139 nTPM
liver: 138 nTPM
choroid plexus: 126 nTPM
adrenal gland: 117 nTPM

Single-cell type

late spermatids: 1,349 nCPM
erythrocytes: 666 nCPM
esophageal apical cells: 644 nCPM
esophageal suprabasal cells: 393 nCPM
epididymal clear cells: 265 nCPM
esophageal basal cells: 245 nCPM

Immune cell

NK-cell: 140 nTPM
plasmacytoid DC: 104 nTPM
memory B-cell: 97 nTPM
total PBMC: 93 nTPM
myeloid DC: 90 nTPM
non-classical monocyte: 88 nTPM

Brain region

choroid plexus: 79 nTPM
thalamus: 63 nTPM
medulla oblongata: 59 nTPM
pons: 59 nTPM
midbrain: 55 nTPM
spinal cord: 54 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.22
gnomAD pLI: 0
gnomAD missense Z: 0.3
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC25A39 as an antibody target. Whether an autoantibody or antibody against SLC25A39 could matter depends on whether native SLC25A39 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC25A39 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC25A39 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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