Seroatlas · Human Serome Atlas

SLC25A35

Solute carrier family 25 member 35

Also known as: FLJ40217, S2535_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q3KQZ1
Gene: SLC25A35
Ensembl: ENSG00000125434
Chromosome: 17
Canonical length: 300 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Vesicles,Mitochondria

OverviewNCBI Gene

SLC25A35 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

300 residues, UniProt reviewed canonical sequence.

>Q3KQZ1|SLC25A35
     1  MDFLMSGLAA CGACVFTNPL EVVKTRMQLQ GELQAPGTYQ RHYRNVFHAF ITIGKVDGLA
    61  ALQKGLAPAL LYQFLMNGIR LGTYGLAEAG GYLHTAEGTH SPARSAAAGA MAGVMGAYLG
   121  SPIYMVKTHL QAQAASEIAV GHQYKHQGMF QALTEIGQKH GLVGLWRGAL GGLPRVIVGS
   181  STQLCTFSST KDLLSQWEIF PPQSWKLALV AAMMSGIAVV LAMAPFDVAC TRLYNQPTDA
   241  QGKGLMYRGI LDALLQTART EGIFGMYKGI GASYFRLGPH TILSLFFWDQ LRSLYYTDTK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC25A35 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 5
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

testis: 24 nTPM
kidney: 17 nTPM
pituitary gland: 12 nTPM
stomach: 12 nTPM
pancreas: 12 nTPM
endometrium: 11 nTPM

Single-cell type

cardiomyocytes: 98 nCPM
syncytiotrophoblasts: 27 nCPM
epicardial cells: 25 nCPM
epididymal principal cells: 21 nCPM
late primary spermatocytes: 19 nCPM
epididymal efferent duct absorptive cells: 16 nCPM

Immune cell

intermediate monocyte: 8.8 nTPM
eosinophil: 7.6 nTPM
non-classical monocyte: 6.5 nTPM
myeloid DC: 5.7 nTPM
classical monocyte: 5.6 nTPM
memory CD8 T-cell: 4.3 nTPM

Brain region

choroid plexus: 8.7 nTPM
thalamus: 8.5 nTPM
medulla oblongata: 7.8 nTPM
white matter: 7.8 nTPM
midbrain: 7.7 nTPM
basal ganglia: 7.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.38
gnomAD pLI: 0
gnomAD missense Z: 0.27
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC25A35 as an antibody target. Whether an autoantibody or antibody against SLC25A35 could matter depends on whether native SLC25A35 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC25A35 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC25A35 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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