Seroatlas · Human Serome Atlas

SLC25A34

Solute carrier family 25 member 34

Also known as: DKFZp781A10161, S2534_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PIV7
Gene: SLC25A34
Ensembl: ENSG00000162461
Chromosome: 1
Canonical length: 304 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Mitochondria

OverviewNCBI Gene

SLC25A34 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

304 residues, UniProt reviewed canonical sequence.

>Q6PIV7|SLC25A34
     1  METVPPAVDL VLGASACCLA CVFTNPLEVV KTRLQLQGEL QARGTYPRPY HGFIASVAAV
    61  ARADGLWGLQ KGLAAGLLYQ GLMNGVRFYC YSLACQAGLT QQPGGTVVAG AVAGALGAFV
   121  GSPAYLIKTQ LQAQTVAAVA VGHQHNHQTV LGALETIWRQ QGLLGLWQGV GGAVPRVMVG
   181  SAAQLATFAS AKAWVQKQQW LPEDSWLVAL AGGMISSIAV VVVMTPFDVV STRLYNQPVD
   241  TAGRGQLYGG LTDCMVKIWR QEGPLALYKG LGPAYLRLGP HTILSMLFWD ELRKLAGRAQ
   301  HKGT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC25A34 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 44 nTPM

Expression across tissuesHPA

Tissue

tongue: 44 nTPM
skeletal muscle: 37 nTPM
cerebellum: 15 nTPM
heart muscle: 13 nTPM
duodenum: 13 nTPM
small intestine: 13 nTPM

Single-cell type

myonuclei: 63 nCPM
enterocytes: 54 nCPM
tuft cells: 23 nCPM
colonocytes: 13 nCPM
enteric transient amplifying cells: 10 nCPM
retinal horizontal cells: 8 nCPM

Immune cell

naive CD4 T-cell: 1.2 nTPM
MAIT T-cell: 0.9 nTPM
memory CD4 T-cell: 0.9 nTPM
naive CD8 T-cell: 0.7 nTPM
memory CD8 T-cell: 0.6 nTPM
NK-cell: 0.6 nTPM

Brain region

cerebellum: 13 nTPM
cerebral cortex: 8.4 nTPM
amygdala: 7.2 nTPM
basal ganglia: 7.2 nTPM
thalamus: 7.2 nTPM
hypothalamus: 6.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.35
gnomAD pLI: 0
gnomAD missense Z: -0.22
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

blastocyst hatching

Cellular components

mitochondrial inner membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC25A34 as an antibody target. Whether an autoantibody or antibody against SLC25A34 could matter depends on whether native SLC25A34 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC25A34 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC25A34 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...