Seroatlas · Human Serome Atlas

SLC25A33

Solute carrier family 25 member 33

Also known as: BMSC-MCP, MGC4399, PNC1, S2533_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BSK2
Gene: SLC25A33
Ensembl: ENSG00000171612
Chromosome: 1
Canonical length: 321 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

SLC25A33 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

321 residues, UniProt reviewed canonical sequence.

>Q9BSK2|SLC25A33
     1  MATGGQQKEN TLLHLFAGGC GGTVGAIFTC PLEVIKTRLQ SSRLALRTVY YPQVHLGTIS
    61  GAGMVRPTSV TPGLFQVLKS ILEKEGPKSL FRGLGPNLVG VAPSRAVYFA CYSKAKEQFN
   121  GIFVPNSNIV HIFSAGSAAF ITNSLMNPIW MVKTRMQLEQ KVRGSKQMNT LQCARYVYQT
   181  EGIRGFYRGL TASYAGISET IICFAIYESL KKYLKEAPLA SSANGTEKNS TSFFGLMAAA
   241  ALSKGCASCI AYPHEVIRTR LREEGTKYKS FVQTARLVFR EEGYLAFYRG LFAQLIRQIP
   301  NTAIVLSTYE LIVYLLEDRT Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC25A33 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

tongue: 26 nTPM
skeletal muscle: 17 nTPM
basal ganglia: 15 nTPM
midbrain: 15 nTPM
cerebral cortex: 13 nTPM
testis: 13 nTPM

Single-cell type

late spermatids: 333 nCPM
müller glia: 331 nCPM
late primary spermatocytes: 271 nCPM
epididymal principal cells: 235 nCPM
early primary spermatocytes: 224 nCPM
rod photoreceptor cells: 194 nCPM

Immune cell

basophil: 2.8 nTPM
memory B-cell: 0.8 nTPM
naive CD4 T-cell: 0.6 nTPM
naive CD8 T-cell: 0.6 nTPM
gdT-cell: 0.5 nTPM
myeloid DC: 0.5 nTPM

Brain region

thalamus: 21 nTPM
cerebellum: 19 nTPM
midbrain: 18 nTPM
hypothalamus: 18 nTPM
spinal cord: 17 nTPM
white matter: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.83
gnomAD pLI: 0.01
gnomAD missense Z: 0.84
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

pyrimidine nucleotide transmembrane transporter activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC25A33 as an antibody target. Whether an autoantibody or antibody against SLC25A33 could matter depends on whether native SLC25A33 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC25A33 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC25A33 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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